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Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Mutations in certain receptors can cause diseases and offer new treatment options.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

Stress-related hair loss was reversed with a special medication.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The document suggests that Alopecia X in dogs is mainly a cosmetic issue and might be better left untreated.

Pigs in farrowing crates and loose-housing systems showed no difference in chronic stress levels as measured by hair cortisol.

The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.

Genes related to calcium signaling and lipid metabolism are important for curly hair in Mangalitza pigs.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Stress hormones like cortisol may trigger psoriasis flare-ups.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.