May 2023 in “GSC biological and pharmaceutical sciences” Forensic DNA phenotyping is becoming useful for predicting physical traits in criminal investigations but is limited by ethical concerns and incomplete genetic understanding.
The mutation helps mice handle heat better without affecting hair growth.
April 2019 in “Actas Dermo-Sifiliográficas” The conclusion is that having both Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus may suggest a shared immune response in certain people, and a mix of antimalarial drugs and 5-alfa-reductase inhibitors is recommended for treatment.
Eating a lot of soy might lower the chance of early hair loss in men likely to get it.
August 2009 in “Journal of Oral and Maxillofacial Surgery” Hair transplantation and micrografting are effective for facial enhancement with nearly 100% graft survival when done carefully.
June 2006 in “Experimental dermatology” Hair follicle bulge cells are important for hair survival and help heal the skin after injury, which might be relevant for understanding hidradenitis suppurativa.
May 2001 in “Journal of Investigative Dermatology” The studies identified key factors and potential treatments for skin and hair disorders.
January 2023 in “The Egyptian Journal of Hospital Medicine” Dutasteride is effective for treating hair loss.
54 citations,
November 1998 in “Archives of dermatology” Avoiding certain nutrients and drugs may help manage pemphigus.
16 citations,
January 2010 in “Journal of Korean medical science/Journal of Korean Medical Science” A Korean boy's skin and digestive symptoms were caused by a rare genetic disorder that affects zinc absorption, and he got better with zinc supplements.
9 citations,
November 2015 in “Plastic and reconstructive surgery/PSEF CD journals” Gene knockout mice developed scars similar to human hypertrophic scars, useful for studying scar progression.
November 2023 in “Journal of Student Research” New treatments like low-level laser therapy, platelet-rich plasma therapy, and micro needling show positive results for hair regrowth in people with genetic hair loss.
May 2023 in “Journal of managed care & specialty pharmacy” Alopecia areata causes hair loss and life quality issues; current treatments are often unsatisfactory, but new drugs like JAK inhibitors show promise.
February 2021 in “Revue médicale de Liège” Platelet-rich plasma injections are a promising new treatment for hair loss, showing initial positive results.
8 citations,
August 2014 in “Biochemical and Biophysical Research Communications” The study investigated the role of ornithine decarboxylase (ODC) in skin carcinogenesis by using genetically modified mice to direct ODC expression to specific epidermal compartments. It was found that K6-driven ODC over-expression in the outer root sheath of hair follicles significantly increased tumorigenesis compared to K14-driven ODC expression in inter-follicular epidermal keratinocytes. Mice with K6-ODC expression developed an average of 15 tumors per mouse, while K14-ODC mice developed 6.8 tumors per mouse. The K6-ODC mice also showed higher UVB-induced proliferation, pro-inflammatory responses, and a greater number of stem-like cells, with reduced Notch1 expression linked to stem cell expansion. The study concluded that ODC enhances tumorigenesis by negatively regulating the Notch pathway, leading to an expansion of the stem cell compartment.
5 citations,
June 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Putting thymidine dinucleotide on newborn mice's skin can delay and reduce skin cancer.
November 2023 in “Biomolecules” The research showed that Vitamin D and its receptor are important for healthy bones and normal hair and skin in rats.
March 2021 in “Berkala Ilmu Kesehatan Kulit dan Kelamin” The best treatment for male pattern baldness is a combination of topical minoxidil and oral finasteride.
12 citations,
January 2021 in “International Journal of Biological Sciences” Scientists successfully edited a goat's genes to grow more and longer cashmere hair.
4 citations,
October 2011 in “International Journal of Dermatology” Bardet-Biedl syndrome may include under-recognized skin problems related to its metabolic disturbances.
2 citations,
February 2014 in “Hair therapy & transplantation” Alopecia Areata is an autoimmune condition causing hair loss, influenced by genetics, environment, and possibly improved by anti-MIF therapy, with many patients experiencing regrowth within a year.
April 2023 in “Medizinische Genetik” New gene discoveries have improved diagnosis and treatment for skin and hair disorders, but more research is needed to fully understand them.
January 2023 in “Przegla̧d dermatologiczny” There are two main types of alopecia areata with different severity, and diagnosis is made through clinical examination and trichoscopy, influencing treatment choices.
October 2021 in “Cosmoderma” Hair loss can be managed with treatments like minoxidil, finasteride, and others, but there are still gaps in effectiveness and off-label usage is increasing.
PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.
AGA causes permanent hair loss; women use 2% minoxidil, men use 1 mg finasteride daily.
January 2012 in “Journal of Practical Dermatology” Various treatments can help manage hair loss in androgenetic alopecia.
April 2008 in “Blackwell Publishing Ltd eBooks” AGA causes permanent hair loss; minoxidil helps men, finasteride helps men, minoxidil somewhat helps women, estrogens/antiandrogens lack evidence for women.
293 citations,
November 2011 in “Nature” The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.
170 citations,
July 2012 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.