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Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.

New treatments for skin and hair disorders in women of color address unique biological differences and include specific acne medications, sunscreens, skin lighteners, and hair care adjustments.

Some skin medications are safe for pregnant women, but others pose risks or should not be used.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Myo-inositol helps improve skin conditions and metabolic profiles in young women with PCOS.

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

Thyroid problems are linked to various skin issues, and checking thyroid health is important for people with certain skin conditions.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

The guidelines help doctors diagnose and treat hormone-related disorders in women.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

A mother and son both had ulcerative colitis and alopecia, suggesting a genetic link in autoimmune disorders and successful treatment with cyclosporine.

Managing diabetes can lead to eating disorders, and eating disorders can make diabetes harder to control.

Understanding skin structure and development helps diagnose and treat skin disorders.

A thorough history and examination are crucial for diagnosing skin diseases, which affect up to a third of people. This includes details about skin lesions, medication, general health, lifestyle, family, and contacts, as well as examining the rash, hair, nails, and mucous membranes. Changes in hair and nails can also indicate other medical and skin disorders.

Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.

Zinc is important for skin health, and supplements can help treat various skin and hair disorders, but more research is needed for conditions like psoriasis and vitiligo.

Certain vitamins in wrong amounts, alcohol abuse, metals, and other toxins can cause serious brain and nerve damage.

The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

A woman with anorexia nervosa improved after treatment for pellagra, reminding doctors to check for this deficiency in patients with eating disorders.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Some diets and supplements might help with skin disorders, but their effectiveness varies and more research is needed.

The man was diagnosed with Cronkhite-Canada syndrome, a rare disorder with GI polyps, skin issues, hair loss, and nail problems.

A balanced diet with proteins, vitamins, and minerals is crucial for managing skin disorders.

The conference concluded that understanding hair and nail disorders is important, iron deficiency may be linked to hair loss, and while some treatments for skin conditions are effective, they may have risks and high costs.

The review suggests that understanding and treating the psychological aspect of skin disorders is important and calls for more collaboration in this field.

The document is a detailed medical reference on skin and genetic disorders.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.