Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the role of mitochondrial dysfunction in the ageing process and reports that its significance compared to other factors in mammalian ageing remains uncertain.

This case report study presents two instances of post-finasteride syndrome, highlighting the persistence of sexual adverse effects despite discontinuation of the drug, and underscores the need for increased awareness and understanding of this condition.

This review discusses the potential of mesenchymal stem cells and their secretome, mainly extracellular vesicles, in Parkinson's disease therapy, highlighting their neuroprotective abilities and therapeutic prospects, but it reports no clinical results.

Hair loss in male frontal fibrosing alopecia may spare areas covered by a wristwatch.

This study found that depression, anxiety, and sleep disturbance were associated with male lower urinary tract symptoms, but these factors did not predict improvement after evaluation and treatment over time.

This retrospective pharmacovigilance study identified 34 drugs, including finasteride and dutasteride, that may be associated with sexual dysfunction, with a higher risk observed in males aged 31-45.

Lichen planopilaris and frontal fibrosing alopecia are likely the same disease with different clinical appearances.

This study suggests that neurosteroids may influence epileptogenesis in a pilocarpine model of temporal lobe epilepsy, as indicated by the modulation of seizure activity following P450 scc upregulation and finasteride treatment in rats.

This consensus from 22 Spanish dermatologists recommends using a multimodal therapy starting with oral dutasteride, combined with topical and/or intralesional agents, and adding hydroxychloroquine if inflammation persists, to manage frontal fibrosing alopecia due to its irreversible hair loss and lack of specific approved treatments.

This study presents cases suggesting that hair transplantation may trigger de novo frontal fibrosing alopecia in some patients, highlighting a potential association worth considering as cosmetic hair procedures become more common.

In this study, researchers found that patients with Friedreich's ataxia exhibited more pronounced ultra-structural hair alterations compared to carriers, likely due to oxidative stress related to deficient frataxin expression.

This review discusses the interrelationship between the anterior pituitary's adrenocorticotropic hormone (ACTH) and the adrenal cortex, but reports no new experimental findings.

In this study, the authors concluded that androgens, but not estrogens, strictly mediate the maintenance of neuromuscular morphology in the spinal nucleus of the bulbocavernosus in adult rats.

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.

This study found a significant discordance between clinical symptoms and dermatoscopic signs with histopathological inflammation in patients with LPP and AFF, affecting diagnostic and therapeutic approaches.

This study found a significant association between finasteride use and increased risk of memory impairment, highlighting the need for risk communication and routine cognitive monitoring for long-term users.

This study found that testosterone impacts hair follicles from both affected and occipital regions in male pattern androgenetic alopecia, but with different androgen response-profiles, challenging the belief that occipital regions are androgen-insensitive.

The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.

This study explores the expression of Snail1 in the fibrotic dermis of postmenopausal women with frontal fibrosing alopecia, suggesting a possible link to epithelial-mesenchymal transition.

The study found that ondansetron decreased alcohol consumption only in adult rats that experienced altered neuroactive steroid levels from early post-natal finasteride exposure, suggesting increased 5HT3 receptor sensitivity in these rats.

This study found that dermoscopy of the axilla in patients with frontal fibrosing alopecia revealed significantly higher odds of brownish peripillary halos, suggesting a diagnostic clue for the condition in this region.

This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.

This study detected a significant association between finasteride use and sexual dysfunction, particularly in younger patients with alopecia, suggesting that indication and reporting stimulation may influence the observed signal.

This study identifies specific trichoscopic features such as empty follicles and perifollicular erythema in Caucasians with frontal fibrosing alopecia, which may assist in diagnosis and monitoring, but stresses the need for further research due to limited demographic data.

This study found that home use of low-level light therapy reduced inflammation and symptoms like itching and burning in women with frontal fibrosing alopecia over six months.

This study found that combining plasma rich in growth factors with conventional treatment significantly improved hair regrowth and reduced symptoms in patients with frontal fibrosing alopecia compared to conventional treatment alone.

This study found that the gut microbiota composition in patients with post-finasteride syndrome differs significantly from healthy controls, with reduced diversity and specific microbial changes, suggesting a potential diagnostic marker and therapeutic target.

This study proposes that combining trazodone and clomiphene citrate could potentially restore libido synaptic circuits and treat post-finasteride syndrome, which involves persistent sexual dysfunction after discontinuing finasteride treatment.

COVID-19 patients with hair loss experienced more cognitive issues and these issues were linked to higher levels of depression, anxiety, and stress.