Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.

This article proposes using the hallmarks of ageing and dysregulated microRNAs to create a molecular morbidity score that could improve prognostication and clinical trial inclusion for patients with multimorbidity.

This review summarizes major surveys on Behcet's disease, highlighting its systemic manifestations, with primary morbidity linked to ocular involvement causing severe vision loss or blindness.

This study found that combined loss of Atr and p53 in adult mice led to severe tissue degeneration and delayed regeneration due to the accumulation of highly damaged cells.

This study investigated premature greying and found lower levels of vitamin D and vitamin B12 in affected individuals compared to controls, associating micronutrient deficiencies with altered hair pigmentation, though no significant link between micronutrient deficiencies and inflammatory markers was observed.

As skin ages, it gets thinner, paler, and more wrinkled, and protection and care like sunblock and moisturizers are important.

This study found that elderly COVID-19 patients are more prone to multiorgan damage, highlighting the need for comprehensive care to lessen the disease's impact.

This review discusses types of hair loss in elderly women, highlighting diagnostic challenges and treatment limitations, but does not present new research findings.

This study presents a new long-term 3D skin model using cells from mature donor skin, showing significant features of skin aging, such as decreased cellular proliferation and hyaluronan content.

This study found that nearly 80% of Finnish adults aged 70 to 93 had at least one skin disease requiring treatment, with men more affected than women.

This article reviews how stem cell exhaustion contributes to aging, emphasizing the balance between proliferation and quiescence as crucial for long-term stem cell maintenance, but it reports no new results.

Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.

This case study reported on a 6-year-old boy with frictional alopecia in the lower limbs, likely linked to his habit of cross-legged sitting and occasional rubbing, highlighting the condition's rarity in pediatric cases and emphasizing the need for further research in this age group.

In this study of elderly patients at an Indian medical center, researchers found that xerosis was the most common physiological skin change and pruritus was the most frequent complaint.

This case report suggests that premature aging may contribute to weakened immunity and the development of autoimmune diseases.

In this study conducted at a tertiary care center, rural elderly patients often exhibited skin conditions like wrinkling, generalized pruritus, xerosis, eczematous skin conditions, and psoriasis, highlighting the need for better health education on skin care, early diagnosis, and management.

In this study, Trf1 genetic deletion in mice, including those with cancer-prone mutations, was shown to not affect overall viability and cause only mild effects, while being necessary for tumor formation, suggesting a potential therapeutic window for Trf1 as an anti-cancer target.

This computational study developed a regulatory model linking key genes and miRNAs to cardiac senescence, validated by connecting 94% of these elements to existing cardiac aging research.

This review examined mechanisms regulating muscle repair, highlighting disruptions in aging and chronic diseases like Duchenne muscular dystrophy and diabetes. It noted that chronic inflammation and metabolic dysfunction hinder effective regeneration and discussed emerging therapies, suggesting multi-target approaches could be promising despite limited clinical evidence.

This study suggests that myotonic dystrophies may qualify as segmental progeroid disorders due to molecular and clinical similarities with typical progeroid syndromes.

This study found that in SAMP8 mice, phenotypic changes in outer hair cells or the stria vascularis, possibly due to oxidative deficiencies, may predict variability in age-related hearing loss before outer hair cell loss occurs.

This article provides no new data as it is a letter to the editor and lacks an abstract, focusing instead on discussing aspects of hair loss in the elderly without presenting research results.

This study reported three related cases of woolly hair syndrome transmitted as a dominant autosomal trait, characterized by fine, frizzy hair and general hair thinning.

This study found that premature hair graying is strongly associated with a family history, Vitamin B12 deficiency, and hypothyroidism, with onset as early as 5 years in patients in Gurugram, India.

This study suggests that while cellular senescence impairs epidermal stem cells in aging, it also serves an essential role during embryonic development, highlighting its dual functional nature.

In this study, researchers investigated the prevalence and types of skin diseases among elders at a medical facility in India, finding that generalised pruritus, seborrheic keratosis, and fungal infections were common, while education on proper skin care may help reduce these conditions.

This study details how very long human hair naturally ages, showing cuticle wear and internal fiber changes that may inform new hair care product designs.

This correspondence suggests that while patients with Raynaud phenomenon may develop connective tissue disorders, physicians should consider this possibility without assuming for certain that progression will occur.

This study identified an unexpected critical role for the FATP4 protein in skin and hair development in mice, linking it to a potential candidate gene for restrictive dermopathy in humans.