28 citations
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January 2012 in “International Journal of Trichology” This study observed that specific trichoscopic features like white peripilar signs, scalp pigmentation, and focal atrichia are associated with advanced female pattern hair loss in Fitzpatrick skin type III patients.
37 citations
,
November 2007 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses how hair care practices impact hair breakage, particularly in patients of color, and reports no clinical results; the authors review testing and measurement advancements and highlight gaps in understanding structural differences.
2 citations
,
August 2023 in “Die Dermatologie” This review discusses the molecular pathology of progeroid syndromes and reports no new results; the authors emphasize understanding these mechanisms to develop treatments and potentially improve quality of life for affected individuals.
January 2022 in “IAR Journal of Parasitology & Infectious Disease” This study observed that 30.1% of older adults had nail changes, predominantly affecting the lower limbs, and hair disorders were less common, with alopecia being the only type recorded.
April 2016 in “Journal of The American Academy of Dermatology” A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.
210 citations
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May 2006 in “The FASEB journal” This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.
November 2022 in “Journal of Investigative Dermatology” This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.
April 2024 in “BMB Reports” This study used Cisd2 knockout mice models and found that these mice display premature aging characteristics and an increase in dysfunctional neutrophils, suggesting Cisd2's role in calcium homeostasis and neutrophil function via interactions with Calnexin and SERCA.
1 citations
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January 2025 in “OBM Geriatrics” This study highlights the role of platelets in immune interactions and severe adenovirus infection, noting that activated platelets have a shorter lifespan. Results suggest potential for developing therapies targeting platelet senescence and immunologic mechanisms.
August 2022 in “International Journal of Health Sciences” Elderly in rural areas have many skin issues needing targeted healthcare.
This study suggests that disruptions in the Ran system related to nuclear transport may be a key factor in the development of cellular issues in Hutchinson Gilford Progeria Syndrome.
3 citations
,
September 2000 in “Geriatric nursing” This review summarizes key characteristics of men's health issues such as erectile dysfunction and prostate cancer, along with specific nursing considerations, and reports no new research results.
59 citations
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November 2010 in “Circulation Research” This review discusses the potential role of Wnt signaling in aging-related heart diseases and reports no clinical results.
April 2023 in “Journal of Investigative Dermatology” This study found that mitochondrial dysfunction in the epidermis contributes to aging-related changes in hair follicles among mice, with aged mice showing reduced hair density and delayed regrowth, suggesting that maintaining mitochondrial function may help prevent age-related organ decline.
28 citations
,
February 2012 in “PLoS ONE” In this study, researchers identified a novel congenital skin disorder in Chesapeake Bay retrievers, linked to a plakophilin-1 deficiency due to a genetic mutation, marking the first known occurrence in an animal species.
98 citations
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December 2015 in “The Journal of Cell Biology” In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.
This chapter reviews various fungal skin diseases affecting cattle but does not report new research findings; it focuses on rare, inherited, and congenital conditions like follicular dysplasia and cutaneous asthenia.
This letter humorously reflects on aging and disputes the notion of "Geezer syndrome" linked to the Great Depression, emphasizing resilience and growth in knowledge over time.
May 2012 in “Surgery (oxford)” This review discusses the challenges patients face after critical illness and suggests that individualized rehabilitation starting in critical care can potentially improve long-term outcomes; it reports no new clinical results.
April 2023 in “Journal of Investigative Dermatology” This study found that mitochondrial dysfunction in T cells led to defective hair follicle stem cell function and premature skin aging signs in a mouse model.
January 2026 in “International Society of Hair Restoration Surgery” This article highlights senescent hair aging as a distinct, underdiagnosed condition from androgenetic alopecia, but reports no new research findings.
2 citations
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June 2016 in “International journal of experimental pathology” This study found that expression of GDNF and GFR α-1 proteins in human skin decreases with age, particularly in the epidermis, suggesting that their signaling pathways may be altered as people grow older.
11 citations
,
June 2016 in “npj Regenerative Medicine” This symposium discussed why regenerative capacity varies among species and diminishes with age, exploring how these insights could inform regenerative medicine approaches, without presenting new experimental results.
60 citations
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November 2023 in “Biology” This review explores the role of aging-related changes in skin, discussing how impaired skin barrier function may contribute to systemic inflammation, or "inflamm-aging," which in turn could impact the broader decline in organ and tissue function seen in aged individuals.
November 2005 in “Physiology” This article highlights advances in various physiological studies, including vitamin E's potential to improve aging-related outcomes in mice, but does not present new experimental results.
October 2021 in “QJM: An International Journal of Medicine” In this study, low serum ferritin levels were significantly associated with premature graying of hair, while no significant difference in vitamin D levels was observed between affected individuals and healthy controls.
January 1974 in “OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)” This study found that hair follicle melanocytes show increased age-related susceptibility to oxidative stress compared to epidermal melanocytes, which may contribute to the graying of hair.
9 citations
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February 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of tissue mechanics and extracellular matrix in skin aging processes and highlights potential therapeutic strategies, but reports no new clinical results.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” This review summarizes the clinical characteristics of Behcet's disease, noting that ocular manifestations are a major cause of morbidity due to their potential to lead to severe vision loss or blindness.
January 2007 in “Revista del Centro Dermatológico Pascua” This case report describes a 2-year-old boy diagnosed with trichothiodystrophy, characterized by fragile hair, intellectual damage, diminished fertility, and short stature.