Progeroid syndromes (PSs) are characterized by early onset of age-related conditions such as hair loss, neurodegeneration, and cardiovascular issues, mirroring natural aging. Recent molecular pathology advances have revealed that genetic mutations in PSs are linked to genome maintenance and repair, highlighting DNA damage accumulation's role in aging. Some genes are directly involved in DNA repair, while others affect genome stability or the DNA damage response. Understanding these mechanisms is essential for developing treatments to manage and prevent PS symptoms, potentially improving the quality of life for those affected.
68 citations
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August 2009 in “American Journal of Medical Genetics Part A” A new classification for trichothiodystrophy helps identify genetic causes and potential treatments.
688 citations
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June 2007 in “Cell Stem Cell” Removing the ATR gene in adult mice causes rapid aging and stem cell loss.
242 citations
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February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
41 citations
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July 2018 in “Frontiers in Neurology” Myotonic dystrophy may be classified as a segmental progeroid disorder.
January 2018 in “Stem cell biology and regenerative medicine” The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.
1 citations
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April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
