Woolly Hair Syndrome: Clinical and Microscopic Study

January 1987 in “ PubMed ”

Bosiljka M. Lalević-Vasić, D Polić

woolly hair syndrome autosomal trait hypotrichosis atrophic follicular keratosis trichorrhexis nodosa trichoschisis trichoptilosis

TLDR Woolly hair syndrome is a genetic condition causing frizzy, fragile hair.

The study reported three cases of woolly hair syndrome within the same family, identifying it as a dominant autosomal trait. The affected individuals exhibited fine, soft, frizzy hair and generalized hypotrichosis. In one case, atrophic follicular keratosis developed during puberty. Laboratory tests showed normal serum and urinary copper and zinc levels. Microscopic examination revealed several hair abnormalities, including flat, oval, or irregular hair shafts, longitudinal and transverse grooves, axial torsions, and damaged or absent cuticle cells leading to early hair fractures. These findings were observed using light microscopy and scanning electron microscopy.

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