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Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

Adolescents with abnormal uterine bleeding often have polycystic ovarian syndrome and insulin resistance.

Ayurvedic treatment, exercise, and a healthy diet can effectively manage PCOD symptoms.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Small molecule IM boosts hair growth by changing stem cell metabolism.

Hdac1 and Hdac2 help maintain and protect the cells that control hair growth.

Inositol and arginine solutions improve hair follicle health and turnover.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Wnt ligands are crucial for hair growth and repair.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Wool follicles are complex, involving interactions between different cell types and structures.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

Androgens prevent hair growth by changing Wnt signals in cells.

Hair follicle regeneration in skin grafts may be possible using stem cells and tissue engineering.

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Human leukocytes and beard hair follicle cells have internal daily clocks, and PER1 and PER3 genes may indicate individual circadian rhythms.

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Ca_v1.2 affects hair growth and could be a target for hair loss treatments.

Hormonal changes after childbirth and menopause can lead to women's hair loss and facial hair growth, with a need for better treatments.

Changing light exposure can affect hair growth timing in goats, possibly due to a key gene, CSDC2.