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This review discusses what is known about the pathobiology of frontal fibrosing alopecia and reports no new clinical findings, highlighting potential environmental and genetic factors in disease pathogenesis.

This study observed that the coexistence of Frontal Fibrosing Alopecia and lupus erythematosus in a patient may suggest a shared pathogenic background.

This source discusses how radiotherapy-induced skin fibrosis, a chronic side effect affecting cancer survivors' quality of life, is driven by ongoing inflammation and fibroblast activity, and emphasizes the need for comprehensive dermatologic management and better diagnostic tools.

This study found that individuals with frontal fibrosing alopecia have increased odds of thyroid disease, lupus erythematous, vitiligo, and heart disease, supporting the consideration of FFA as a systemic disorder.

This study found that in murine dermis, fibroblast state switching between proliferation and ECM deposition plays a crucial role in tissue architecture and wound healing.

This study identified that bone marrow-derived CD34⁺ cells act as fibroblast progenitors to enhance tissue regeneration in ischemic limbs by promoting angiogenesis through interactions with macrophages.

This narrative review highlights current insights into how perifollicular fibrosis contributes to androgenetic alopecia, by hindering hair regrowth and treatment response, and outlines potential antifibrotic therapies, though conclusive evidence from randomized controlled trials is still needed.

Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.

In this case report, researchers observed that two sisters with congenital immune disorders experienced partial hair regrowth while receiving tofacitinib for severe alopecia areata, highlighting the need for careful clinical and laboratory monitoring due to potential infection risks associated with JAK inhibitor therapy.

This study identified a crucial Gli2-Serpinh1 regulatory axis that regulates fibroblast state transitions during skin wound healing, shedding light on fibroblast heterogeneity and suggesting potential precision regenerative therapies.

This review reports that empirical evidence suggests an overlap between Long Covid, chronic fatigue syndrome, and fibromyalgia, highlighting the need for standardized definitions and rigorous methodologies in related research.

This study found that frontal fibrosing alopecia and lichen planopilaris have similar histopathological features, but FFA exhibits more prominent apoptosis and less inflammation with spared interfollicular epidermis.

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

This review discusses the various factors implicated in the etiology of frontal fibrosing alopecia and notes the need for effective treatments, reporting no new clinical findings.

This research highlights a hydrogel system that could significantly improve diabetic wound healing by releasing ibuprofen to both suppress inflammation and promote tissue regeneration, indicating a strong potential for future clinical use.

Among patients with biopsy-proven FAPD in specialized hair clinics, this study found the condition is common in females around 52.5 years old, with treatment generally stabilizing or slightly improving hair loss, despite challenges in differentiating FAPD from androgenetic alopecia.

In this study, tofacitinib showed promising efficacy and safety for biologic-naïve elderly patients with moderate-to-severe ulcerative colitis, achieving steroid-free remission and clinical response over 52 weeks.

This study found that fibroblast behavior switching between proliferation and ECM deposition is vital for dermal architecture, where cell migration is primarily important for tissue repair during wound healing.

This study reported two cases where infliximab-associated psoriasiform alopecia resolved with significant hair regrowth after stopping infliximab and using potent topical steroid treatment.

This study found that Forsythiaside A may protect against sepsis-induced acute kidney injury in mice by reducing inflammation and apoptosis through modulation of ER stress responses.

This case study suggests that intense inflammation after photodynamic therapy may trigger or worsen fibrosing alopecia in susceptible individuals.

This correspondence discusses interpretative challenges in a recent study on fibrosing alopecia, highlighting that observed disease stabilization may not imply lasting control due to diagnostic inconsistencies.

This study reported that NLRP3 plays complex roles in wound healing by initially promoting inflammation and delaying repair, but later enhancing structural restoration through distinct signaling pathways, highlighting its potential as a therapeutic target for controlling inflammation and regeneration phases.

Tofacitinib may effectively treat folliculitis decalvans.

In this case report, the researchers described two women with Crohn disease who developed alopecia related to TNF inhibitor therapy, noting various histopathological features of drug-induced alopecia and treating it effectively with different therapeutic approaches.

This study investigated the impact of the JAK inhibitor ruxolitinib on APS-1 patients, reporting that treatment decreased excessive T-cell-derived interferon-γ, normalized inflammatory markers, and led to remission of several autoimmune symptoms without serious adverse effects.

This case study suggests that treatment with Pil-Food, intended for hair loss prevention, may have triggered postinfantile giant cell hepatitis with autoimmune characteristics, which showed a rapid and effective response to corticosteroid therapy.

In this study, dihydrotestosterone increased proliferation and decreased IL-6 production in in-vitro fibroblasts from hereditary gingival fibromatosis and normal gingiva, effects partially reversed by anti-androgens.

This study found that IL-1 blockers are effective for SURF and identified predictors of colchicine resistance, emphasizing the need for refined diagnostic criteria and personalized treatment due to the heterogeneity observed within SURF.