A Clinical Case of Familial Alopecia Areata in Combination with Immune Pathology

    July 2025 in “ Russian Journal of Clinical Dermatology and Venereology ”
    Н. Н. Потекаев, О. В. Жукова, Aida Gadzhigoroeva, G. P. Tereshchenko, S. I. Artemyeva, I.A. Mikhaylova, М. A. Kochetkov, V.Yu. Udzhukhu
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    TLDR Tofacitinib may help hair regrowth in familial alopecia areata with immune issues, but more research is needed.
    The document discusses a clinical case involving two sisters with familial alopecia areata and congenital immune disorders, emphasizing treatment challenges. The older sister, 24, has primary immunodeficiency with selective IgA and IgG2 deficiencies, while the younger sister, 18, is suspected of having an antibody defect. Both are treated with tofacitinib, leading to partial hair regrowth, more notably in the younger sister. The case highlights the need for collaboration among dermatologists, immunologists, and geneticists and suggests potential use of JAK inhibitors, though further research is necessary to validate their effectiveness and safety.
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