Effectiveness and Safety of Tofacitinib in Biologic-Naïve Elderly Patients with Ulcerative Colitis

    January 2025 in “ Journal of Crohn s and Colitis ”
    A Singh D.M., Vandana Midha, A Bhardwaj, Rajesh Sharma, Dharmatma Singh, Rajesh Mahajan, Ajit Sood
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    TLDR Tofacitinib is effective and safe for elderly patients with ulcerative colitis.
    This study evaluated the effectiveness and safety of tofacitinib in 35 biologic-naïve elderly patients (≥60 years) with moderate-to-severe ulcerative colitis at a tertiary care center in North India. The primary outcome, steroid-free clinical remission at both weeks 8 and 52, was achieved in 25.71% of patients. At week 8, clinical remission, steroid-free remission, and clinical response were observed in 51.42%, 42.85%, and 62.85% of patients, respectively. By week 52, these rates increased to 62.85% for both clinical remission and steroid-free remission, with a clinical response in 77.14% of patients. Common adverse events included hair loss (17.14%), sadness of mood (11.42%), and dyslipidemia (8.57%). The findings suggest that tofacitinib is a viable treatment option for this patient population.
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