Clinical Case of Tofacitinib Therapy in Autoimmune Alopecia in Patient with Ulcerative Colitis

The document discusses a clinical case where a patient with ulcerative colitis, sacroiliitis, and alopecia was treated with the Janus kinase inhibitor, tofacitinib. This treatment led to disease remission, reduced activity of ulcerative colitis and sacroiliitis, and the resumption of hair growth. However, when the dose of tofacitinib was reduced to 10 mg/day, the patient experienced hair loss again, despite the remission of ulcerative colitis being maintained. The document concludes that tofacitinib therapy can effectively stimulate hair growth in alopecia patients, but hair loss may recur if the therapy is stopped or reduced.