TLDR Tofacitinib improved ulcerative colitis, skin ulcers, and hair loss in a patient who didn't respond well to other treatments.
The document reports a case where an 80-year-old female patient with ulcerative colitis (UC), pyoderma gangrenosum (PG), and alopecia areata (AA) experienced improvement in all three conditions after being treated with tofacitinib, a pan-janus kinase (JAK) inhibitor. The patient had previously been treated with oral aminosalicylates, systemic and intralesional corticosteroids, topical tacrolimus, adalimumab, and methotrexate, with only partial response or nonresponse. In July 2020, she was prescribed 11 mg/day of tofacitinib XL, which led to clinical remission of UC by September 2020, as well as marked improvement in both AA and PG, without any adverse events. This case highlights the potential of tofacitinib to simultaneously treat multiple autoimmune conditions in patients who have not responded to other systemic biological and immunosuppressive medications.
8 citations
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June 2022 in “Frontiers in Medicine” Both individual and combined treatments of tofacitinib and corticosteroids can help regrow hair in moderate-to-severe alopecia areata, but ongoing treatment may be necessary.
7 citations
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March 2022 in “Journal of the American Academy of Dermatology” Tofacitinib can regrow hair in alopecia areata patients, but some may experience flares during treatment.
4 citations
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January 2022 in “Dermatologic Therapy” Tofacitinib was found to be a safe and effective treatment for hair regrowth in patients with alopecia areata.
11 citations
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February 2021 in “Journal of Cosmetic Dermatology” Oral tofacitinib helped regrow hair in over half of the patients with severe alopecia, but relapses and side effects were common.
79 citations
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September 2018 in “Dermatologic therapy” Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.
4 citations
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July 2018 in “PubMed” Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.
24 citations
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January 2018 in “International Journal of Trichology” Tofacitinib helped regrow hair in patients with alopecia, with few side effects.
16 citations
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January 2017 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” A patient with complete hair loss regrew all her hair using tofacitinib.
70 citations
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July 2016 in “Experimental Dermatology” A patient with alopecia areata regrew hair after taking tofacitinib and showed changes in certain blood and skin markers.
