9 citations
,
June 2024 in “Genes” This study examined the Spanish Merino breed's wool quality, identifying 74 genetic variants linked to key wool traits like fiber diameter and staple length, which could help restore the breed's potential for producing high-quality wool.
5 citations
,
April 2021 in “Journal of Mind and Medical Sciences” This review examines the interconnected roles of bone, adipose tissue, and the central nervous system in regulating energy balance, providing no new experimental results.
1 citations
,
January 2025 in “Poultry Science” In this study, researchers examined skin growth and quality in Pekin ducks from 1 to 6 weeks of age, finding that skin factors like strength and collagen content increased with age and were influenced by gene expressions related to cell proliferation and collagen synthesis.
December 2022 in “Journal of Natural Remedies” This study found that compounds extracted from Cucurbita maxima seeds at 50 °C for 2 hours demonstrated significant binding affinities against breast cancer-related proteins, suggesting potential anticancer activity needing further in vitro and in vivo evaluation.
24 citations
,
July 1994 in “Molecular Endocrinology” Researchers found an RNA transcript that might help control a growth factor linked to tumor development.
46 citations
,
December 2001 in “Journal of Endocrinology/Journal of endocrinology” This study found that mouse FLRG protein, a secreted glycoprotein, is expressed in certain tissues and plays a role distinct from follistatin during wound healing, suggesting different functions in vivo.
25 citations
,
May 2013 in “Journal of mammary gland biology and neoplasia” This review examines the roles of Hedgehog and Gli proteins in mouse embryonic mammary development and suggests that Gli3-repressor-mediated off-state of Hedgehog signaling determines mammary fate over hair follicle fate.
November 2013 in “John Wiley & Sons, Ltd eBooks” This chapter reviews various mucocutaneous manifestations of endocrine disorders and provides illustrative images of these clinical features, but reports no new research findings.
June 2007 in “Endocrinology and Metabolism Clinics of North America” This study reports that incomplete information in a reverse supply chain can lead to efficiency losses, but a two-part tariff contract for the remanufacturer may improve performance by eliciting private information from collectors.
788 citations
,
February 2007 in “Nature” This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.
182 citations
,
November 2017 in “Molecular Aspects of Medicine” This review discusses various therapeutic strategies targeting platelet-derived growth factor signaling in diseases like cancer and atherosclerosis, and evaluates existing treatments without presenting new clinical data.
107 citations
,
August 2012 in “Seminars in Cell & Developmental Biology” This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.
100 citations
,
November 1996 in “Molecular Medicine Today” This review discusses the role of growth factors and cytokines in hair follicle development and cycling, but reports no new clinical findings on treatments for hair growth disorders.
1 citations
,
June 2013 in “Science-business Exchange” In this study, researchers at the University of Pennsylvania found that increasing FGF9 levels in wounded mouse skin can lead to the growth of hair follicles.
January 2019 in “Springer eBooks” Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in a mouse model of Focal Dermal Hypoplasia, treatment with lithium carbonate improved skin disease symptoms compared to controls, though disease severity varied and posed interpretation challenges.
November 2017 in “International journal of research in dermatology” This case report describes a rare instance of nevus comedonicus with a multi-dermatomal unilateral pattern along the lines of Blaschko, treated unsuccessfully with topical tretinoin and oral retinoids.
1533 citations
,
October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
301 citations
,
May 1998 in “Genes & Development” Ets2 gene is crucial for placental development in mice.
199 citations
,
January 2004 in “The International Journal of Developmental Biology” This review discusses advances in understanding hair and hair follicle structure, gene expression, and molecular signals in hair formation, without reporting new clinical findings.
106 citations
,
September 2010 in “Stem cells” This study found that skin-derived precursor cells in mice can originate from both neural crest and somite lineages but show functional similarities regardless of their developmental origins.
42 citations
,
September 2015 in “Gene” This study demonstrated that FGF5s acts as an inhibitor of FGF5 in regulating hair growth cycles in cashmere goat dermal papilla cells.
41 citations
,
December 2019 in “Stem Cell Reviews and Reports” This review discusses the progress in tooth regeneration research and highlights the potential of spatial-temporal release of developmental factors, but it reports no new clinical findings.
23 citations
,
May 2020 in “Cell Death and Disease” This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.
10 citations
,
April 2013 in “Journal of Investigative Dermatology” This study found that ovine dermal papilla cells exhibit robust aggregation in culture, offering a model to investigate the regulation of hair follicle dermal papilla size.
8 citations
,
August 2020 in “Experimental dermatology” This study observed that platelet-rich plasma samples from female patients show significant variability in growth factor secretion, which may influence the inconsistent clinical response in alopecia treatment.
4 citations
,
January 2015 in “Journal of clinical & experimental dermatology research” This study observed a slight improvement in hair density in men with androgenetic alopecia treated with autologous platelet rich plasma, but only two cases showed cosmetic improvement.
2 citations
,
February 2024 in “Nature cell biology” In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.
1 citations
,
April 2025 in “Pediatria i Medycyna Rodzinna” This research re-analyzed single-cell gene expression data from a mouse model, confirming that certain genes involved in the EDA-EDAR and WNT pathways are crucial for skin appendage development, suggesting that their restoration may mitigate the effects of hypohidrotic ectodermal dysplasia in children.
1 citations
,
February 2021 in “Scholars international journal of anatomy and physiology” In a laboratory setting, this study found that overexpression of the FGF5 short form in cultured keratinocytes increased hepatic growth factor gene expression, suggesting a potential role in hair growth.