60 citations
,
February 2010 in “Gynecological Endocrinology” This study suggests that adding metformin to diet and exercise improves insulin resistance and hyperandrogenism in women with PCOS, though lifestyle changes alone may enhance menstrual cycles.
19 citations
,
July 2013 in “The obstetrician & gynaecologist” This review discusses diagnostic criteria for polycystic ovary syndrome and highlights the challenges and risks of misdiagnosing women with other hyperandrogenism causes; it reports no clinical results.
May 2021 in “Journal of the Endocrine Society” This case report details a diagnosis of adult-onset isolated hypogonadotropic hypogonadism in a 23-year-old African American female, highlighting its genetic basis and treatment approach.
March 2013 in “Reactions Weekly” A man's fertility improved after he stopped taking finasteride but worsened again when he restarted the medication.
May 2026 in “Journal of Assisted Reproduction and Genetics” In this study, researchers developed and tested a novel peptide, AMHR2BP, which mimics the function of Anti-Müllerian hormone to protect ovarian follicles in mice, showing promise for preserving ovarian health during chemotherapy without causing toxicity.
October 2010 in “Journal of Men's Health” Larger prostate size in older men may be linked to poorer semen quality and fertility issues.
4 citations
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May 2019 in “Reproductive Endocrinology” This article reviews the causes and diagnosis of hyperandrogenism, highlighting its impact on female fertility and the metabolic risks associated with PCOS, but it provides no new clinical results.
September 2012 in “The Egyptian Journal of Histology” In this study, flutamide at therapeutic doses caused significant histological changes in the testes and epididymis of adult albino rats, reducing androgen receptor immunoreactivity and increasing estrogen receptor immunoreactivity.
June 2011 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)” The researchers reported that both estrogen receptors ERα and ERβ are expressed in human testis, and identified two novel genes, Aven and Regucalcin, linked to estrogen and androgen regulation, which may be crucial for spermatogenesis.
April 2026 in “AMEI's Current Trends in Diagnosis & Treatment” This review discusses the symptoms, causes, and treatment options for polycystic ovary syndrome and reports no new results; the authors highlight the role of lifestyle changes, medications, and fertility treatments.
11 citations
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May 2024 in “Reproductive Biology and Endocrinology” In this study, researchers found that human ovaries at different life stages biosynthesize both canonical and non-canonical steroid hormones, with fetal ovaries showing higher enzyme activity related to estradiol and testosterone conversion compared to adult tissues.
4 citations
,
January 2014 in “Dermatology” This case report details a woman with autoimmune primary ovarian insufficiency linked to hormonal contraception discontinuation, who achieved pregnancy through ovarian stimulation and in vitro fertilization despite typically low fertility in such conditions.
1 citations
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January 2025 in “ARC Journal of Nursing and Healthcare” This study focused on overweight and obese women with polycystic ovary syndrome who underwent lifestyle modification interventions and found notable improvements in BMI, menstrual cycle regularities, hyper-androgenic symptoms, and fertility outcomes, including a 36.2% pregnancy rate post-intervention.
June 2025 in “General medicine and Clinical Practice” This study found that a lifestyle modification program significantly improved androgenic alopecia, acne vulgaris, and hirsutism levels in infertile overweight and obese women, with 36.2% achieving pregnancy post-intervention compared to none before, suggesting enhanced fertility and reduced hyperandrogenism.
January 2026 in “Scholars Journal of Medical Case Reports” This article outlines a diagnostic and treatment approach for polycystic ovarian syndrome in young women, emphasizing lifestyle modifications, hormonal treatments, and specialist referrals for managing symptoms and fertility concerns.
This study presents the G4 transgenic mouse model, which suggests a direct link between polycystic ovary syndrome and the Gm10800 gene, offering a valuable tool for understanding the disease and testing treatments.
May 2025 in “International Journal of Innovations in Science Engineering and Management.” This study reviewed the literature on cryptorchidism in dogs and found it may be associated with dermatological issues like alopecia, with surgical intervention and cyclosporine offering partial benefit.
This study found that Anovlar effectively reduced pain in severe dysmenorrhea cases and regulated cycles in oligomenorrhea patients, but some side effects and occasional treatment failures were reported.
March 2012 in “Journal of the American Academy of Dermatology” Treating ovarian-related inflammation may help hair regrowth in women with alopecia areata.
18 citations
,
August 2011 in “Medical Hypotheses” This article discusses the relationship between sedentary behavior and chronic disease, proposing that "physical inactivity disease" may be a non-permissive brain disorder with various physiological effects, but it reports no new research results.
April 2025 in “The American journal of patient health info.” This source highlights that women with PCOS often face hormonal imbalances leading to symptoms like irregular menstrual cycles and increased risks of conditions such as infertility and type 2 diabetes, while lifestyle changes remain crucial for managing PCOS.
January 2025 in “Case Reports in Medicine” In this case study, a diagnosis of HAIR-AN syndrome, a rare form of polycystic ovarian syndrome, was made in a 17-year-old female with hyperandrogenism, insulin resistance, and acanthosis nigricans, but genetic screening revealed no significant mutations linked to her symptoms.
April 2023 in “Elsevier eBooks” This review summarizes the prevalence and range of health issues associated with polycystic ovary syndrome in North America but does not provide new clinical findings.
January 2023 in “Indian dermatology online journal” This case study describes a previously unknown association of the PIBIDS complex with autoimmune thyroiditis and autoimmune hemolytic anemia in a five-year-old Indian child.
This review discusses the diagnostic criteria and management challenges for polycystic ovarian syndrome and reports no clinical results, highlighting complications associated with pregnancy in women with the condition.
87 citations
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July 2018 in “Nursing Clinics of North America” This review discusses the diagnostic criteria and treatment options for polycystic ovary syndrome focusing on metabolic subtypes and reports no clinical results.
5 citations
,
October 2022 in “Heliyon” This review discusses infertility in polycystic ovary syndrome and therapeutic options, without reporting new results; it underscores the importance of personalized treatment plans based on patient needs and disease characteristics.
237 citations
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February 2016 in “Science Translational Medicine” This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
81 citations
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May 2007 in “Fertility and Sterility” This review discusses the safety of testosterone therapy for postmenopausal women and concludes that, aside from hirsutism and acne, it appears safe at physiological doses for several years, though more long-term studies are needed.
2 citations
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November 2020 in “Fertility Research and Practice” This study presents a new survey instrument that was cognitively tested for understanding menstrual cycle characteristics and androgen excess, including hirsutism, alopecia, and acne.