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In this cohort study of young Danish men, self-reported older age at voice break was linked to certain reproductive hormone changes that suggest reduced male fecundity, but associations with semen characteristics and testicular volume were not statistically significant.

This review suggests that finasteride is well-tolerated and potentially more effective than other treatments for hirsutism, with results confirmed by other studies.

This study suggests that metformin might serve as a diagnostic and therapeutic option to distinguish insulin resistance-related ovarian testosterone excess from a testosterone-secreting tumor in women with virilization.

In this study, abnormal glucose tolerance was found to be prevalent among young Indian women with PCOS, and the use of an oral glucose tolerance test significantly improved its detection.

This study found that spironolactone reduced serum androstenedione and anagen hair shaft diameter in hirsute patients but did not significantly alter unbound testosterone levels, suggesting its effects are primarily peripheral.

In this study, insulin resistance in polycystic ovary syndrome was highly correlated with unbound testosterone and sex hormone-binding globulin, rather than luteinizing hormone or peripheral androgen metabolism.

This study found that approximately 75% of women with PCOS exhibited hyperandrogenemia, with free testosterone being the most frequently elevated marker.

This study found that spironolactone was significantly more effective than finasteride in reducing hirsutism scores over 9 months, despite more side effects occurring in the spironolactone group.

This study suggests that androgen receptor gene CAG repeat length may influence serum free testosterone levels in some PCOS patients, with longer repeats associated with higher testosterone concentrations.

This study found that oral contraceptives effectively suppressed hyperandrogenemia in most patients with hyperandrogenic-insulin-resistant acanthosis nigricans syndrome, though GnRH-a therapy was beneficial for those not responding initially.

This study reported that ketoconazole may effectively normalize menstruation and reduce testosterone and hair growth in women with ovarian hyperandrogenism, though its safety needs further evaluation.

Finasteride helps induce ovulation in nonresponder PCOS women.

This study observed that adult offspring of sperm donation generally feel positive about their conception method and believe identifying information about donors should be accessible.

In this study, women with PCOS were at higher risk of depression, particularly those with morbid obesity, but other symptoms like elevated testosterone and skin manifestations were not linked to increased depression risk.

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

This study found that reproductive gynecologists are the primary source of referrals for male infertility evaluations, with many men referred before completing a male factor investigation even when using assisted reproductive technologies or lifestyle factors like testosterone replacement.

This study concluded that finasteride, cyproterone acetate, and flutamide were similarly effective at reducing hirsutism in women, though they acted through different mechanisms.

This study found that spironolactone reduced testosterone production and urinary 17-ketosteroid excretion, leading to a decrease in hair growth rate and a change in hair texture in women.

In this case study, clomiphene citrate therapy restored hormonal balance and improved symptoms in a young male runner with hypogonadotropic hypogonadism related to endurance exercise.

In this study, pioglitazone treatment in insulin-resistant PCOS patients decreased relative 5alpha-reductase activity without significantly affecting cortisol levels or urinary cortisol excretion.

This study suggests that in women with androgenic alopecia and men with premature balding, enhanced 5α-reductase activity and altered androgen conjugation, favoring sulfurylation, may be involved in scalp hair loss.

In this study, treatment with flutamide combined with a low-dose oral contraceptive significantly improved hirsutism in women with polycystic ovarian disease who did not respond to oral contraceptive treatment alone.

This case report highlights that a postmenopausal woman experienced virilization due to unintentional transdermal absorption of testosterone from her spouse's topical androgen via shared washcloths, underscoring the importance of considering exogenous androgen exposure in similar diagnoses.

This study found that girls with polycystic ovary syndrome and longer SHBG and AR gene repeats experienced greater improvements in lipid and androgen levels after one year of metformin treatment.

In this study, patients with polycystic ovary syndrome self-reported higher hirsutism scores compared to clinician assessments, but only clinician scores correlated with biochemical markers of hyperandrogenism.

This study found that in women with acne vulgaris, lower serum levels of 3α-androstanediol-glucuronide suggest reduced 5α-reductase activity compared to controls, indicating that 5α-reductase inhibitors may not be effective for acne treatment.

This review discusses the emerging considerations and challenges of uterus transplantation for transgender women but presents no new clinical results.

In this study, biochemical and clinical hyperandrogenism in PCOS were found to be distinct entities with no strong androgen correlation to clinical symptoms like acne or hirsutism.

This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.

This study found that women with PCOS have higher follicular fluid levels of testosterone and IL-6, despite similar NEFA levels to non-PCOS women, suggesting increased lipotoxicity impact on androgenesis in PCOS.