Idiopathic Hypogonadotropic Hypogonadism in a Male Runner Reversed by Clomiphene Citrate

    April 1997 in “ Fertility and sterility ”
    Mark R. Burge, Richard A. Lanzi, Shayne Skarda, R. Philip Eaton
    TLDR Clomiphene citrate can reverse low hormone levels and symptoms in male runners with hypogonadotropic hypogonadism.
    A 29-year-old male runner with idiopathic hypogonadotropic hypogonadism, characterized by low LH, FSH, and testosterone levels, was treated with clomiphene citrate (CC) at doses up to 50 mg twice daily for 5 months. This treatment normalized his hormone levels and improved clinical symptoms, including erectile function, testicular size, sexual hair growth, and overall well-being. The study suggested that exercise-induced hypogonadotropic hypogonadism is a clinical condition in male endurance athletes and that CC could be a safe and effective treatment for this condition.
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