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The document is a detailed medical reference on skin and genetic disorders.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

Forensic hair analysis for drugs is now more reliable and accurate.

Skin changes can indicate starvation and nutritional deficiencies in anorexia nervosa.

Some blood-thinning medications can increase the risk of bleeding, and certain factors like genetics and other health conditions affect their safety and effectiveness.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Fat-related cells are important for initiating hair growth.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Fat cells help recruit healing cells and build skin structure during wound healing.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.