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This study found that extracellular Granzyme B contributes to skin aging and impaired healing in ApoE knockout mice by degrading essential extracellular matrix components like decorin and fibronectin.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This review highlights the potential of exosomes, particularly their microRNA components, as promising candidates for developing effective hair loss treatments by exploring their roles in hair follicle development and regeneration.

This study suggests that activating the hexosamine pathway may enhance skin homeostasis, potentially increasing hair follicle stem cells and modifying extracellular matrix components like hyaluronic acid in vitro.

Epithelial cell growth in rat hair follicles needs contact with mesenchymal cells through the extracellular matrix.

This review highlights recent advancements in the engineering of skin organoids using hydrogels, which improve their structural and functional fidelity by supporting the architecture and integration of vascular and neural components, promising to enhance regenerative medicine, drug discovery, and complex skin disorder studies.

This study developed a novel hydrogel combining Chlorella extracellular polysaccharide–selenium nanoparticles (EPS-SeNPs) with biocompatible components, which demonstrated strong antibacterial and anti-inflammatory effects, significantly accelerating wound healing in an infected rat model, and enabling pH-based monitoring of healing.

This study found that age-related changes in scalp dermal fibroblasts, including increased MMP-1 and reduced ECM components, may significantly affect the hair follicle environment and contribute to hair aging.

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

This study observed that cultured dermal papilla cells showed distinct functional properties from dermal fibroblasts, including lower proliferation rates, higher adhesion to collagen type IV, and different cell-matrix interactions.

This article discusses the distribution of extracellular matrix molecules in human hair follicles and reports no new results.

In this study, researchers developed a fast-dissolving microneedle patch delivering minoxidil nanoparticles and plant-derived vesicles, which improved hair regrowth and follicle health in a mouse model of androgenetic alopecia by reducing oxidative stress and inflammation without causing skin irritation or systemic toxicity.

This study found that generating pluripotent stem cell-derived skin organoids in a 3D bioprinted hydrogel device improved keratinocyte differentiation and hair follicle formation while reducing necrosis.

This study found that small extracellular vesicles derived from human adipose tissue could promote soft tissue regeneration and increase M2 macrophage polarization, suggesting a promising cell-free approach to tissue repair.

This review focuses on hydrogel microsphere-mediated strategies to improve organoid culture by addressing deficiencies in extracellular matrix organization, potentially enhancing the physiological accuracy and clinical translatability of osteomuscular in vitro models as reported in this study.

In this laboratory study, researchers found that a methanol extract of peach kernel improved the growth and viability of human hair follicle dermal papilla cells, suggesting its potential efficacy for hair growth and care through cell proliferation and signaling pathways activation.

This study summarizes the signaling molecules and extracellular components involved in epithelial–mesenchymal interactions, enhancing our understanding of hair follicle regeneration and skin wound healing, but reports no new experimental results.

This review examines the potential mechanisms by which stem cell-derived cell-free therapy may prevent skin aging, highlighting various molecular targets and pathways involved in regeneration, oxidative stress regulation, ECM preservation, cell activity modulation, and inflammation.

This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.

This study found that Gelatinase A activity is linked to the absence of type VII collagen during human fetal skin development, indicating its role in remodeling the basement membrane zone.

This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.

In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.

This review examines the roles of Hyaluronic Acid and Versican in the skin extracellular matrix and reports no new research findings, highlighting their involvement in processes like differentiation and wound healing.

Skin aging helps us understand overall aging.

This review discusses the role of fascial mobilization in wound healing and its potential implications for treating chronic skin wounds and scarring, but reports no new clinical results.

This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.

This review discusses the enhanced understanding of how stem cell niches respond adaptively to systemic signals, aging, and local perturbations, but reports no new research findings.

This review summarizes existing evidence on how YAP and TAZ proteins are activated in epidermal keratinocytes and their role in coordinating with other signaling molecules to control transcription and influence epidermal cell fate, highlighting their importance beyond the Hippo pathway.

Dog hair follicles contain important molecules that may affect hair growth.

This review discusses the role of traditional Chinese medicine and bioactive materials in chronic wound healing and reports no new clinical results.