Aging of the Skin

January 2019 in “ Elsevier eBooks ”

Christos C. Zouboulis

skin aging keratinocytes fibroblasts hair follicle cells extracellular matrix collagen elastin

TLDR Skin aging helps us understand overall aging.

The document discussed how skin aging served as a visible indicator of the aging process in the entire organism due to its accessibility and the ability to study its cellular and non-cellular components. The skin's cellular components, such as keratinocytes, fibroblasts, and hair follicle cells, along with non-cellular components like the extracellular matrix, collagen, and elastin, provided a model for understanding the molecular mechanisms involved in aging. This made the skin a valuable "key hole" for observing and assessing the aging process.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage

30 citations , November 2013 in “PLOS ONE”

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

67 citations , August 2013 in “International Journal of Cosmetic Science”

Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.

research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline

211 citations , April 2013 in “Development”

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

research A Matter of Life and Death: Self-Renewal in Stem Cells

150 citations , December 2012 in “EMBO Reports”

Stem cell self-renewal is complex and needs more research for full understanding.

research Age-Associated Inflammation Inhibits Epidermal Stem Cell Function

144 citations , September 2012 in “Genes & development”

Aging causes skin stem cells to work less effectively.

research Actinic Keratosis: A Clinical and Epidemiological Review

89 citations , June 2012 in “Anais Brasileiros de Dermatologia”

Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

330 citations , December 2009 in “Cell stem cell”

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research Human Skin Stem Cells and the Aging Process

143 citations , September 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

research A Review of Aging and an Examination of Clinical Methods in the Assessment of Aging Skin. Part 2: Clinical Perspectives and Methods

78 citations , September 2008 in “International Journal of Cosmetic Science”

The document concludes that various clinical methods are used to assess ageing skin and the effectiveness of anti-ageing products.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations , June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

research Sexual Hormones in Human Skin

305 citations , February 2007 in “Hormone and metabolic research”

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

research Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage

210 citations , May 2006 in “The FASEB journal”

Oxidative stress causes hair to gray by damaging and killing pigment cells.

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 75 upvotes 1 year ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

in Research/Science 131 upvotes 3 months ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 1 month ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Anti-oxidants that reverse hairloss?

in Research/Science 89 upvotes 4 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Minoxidil and skin aging worry – which prevention methods (platelet rich plasma, microneedlig, mesotherapy, stem cells, co2, ultherapy, …)

in Chat 4 upvotes 3 years ago

User started minoxidil, noticed forehead lines and dark circles, and asked for non-invasive skin aging prevention methods. Another user suggested using tretinoin and hyaluronic acid for long-term benefits.

Related Research

2 / 2 results

research Oral Tofacitinib: A Promising Treatment in Atopic Dermatitis, Alopecia Areata, and Vitiligo

37 citations , October 2017 in “Clinical and Experimental Dermatology”

Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.

research Common Dermatologic Conditions

14 citations , April 2014 in “Medical Clinics of North America”

The document concludes that quick referral and appropriate treatments are crucial for managing common skin conditions and preventing permanent damage.