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This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.

This review highlights the potential of nano-phytopharmaceuticals in improving the bioavailability and efficacy of phytochemicals for treating locomotor, dermal, reproductive, and urinary tract disorders, but notes that more clinical and preclinical research is needed to establish their safety and efficacy for human use.

This study reports that Asparagus racemosus and Withania somnifera extracts significantly reduced paclitaxel-induced myelosuppression and morbidity in mice, suggesting their potential as therapeutic adjuvants in cancer management.

This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.

This study suggests that gendered social factors, in addition to biological differences, contribute significantly to sex disparities in adverse drug event reports, with patient and event type influencing observed differences.

In this retrospective cohort study, researchers found that persistent discontinuation of gender-affirming hormones among transgender adolescents was rare, mainly due to achieving gender expression goals or access issues, with very few reidentifying with their birth-assigned sex.

This study developed and initially validated the Scale of Alopecia Areata Distress (SAAD), a 41-item tool designed to measure psychosocial distress among US adults with alopecia areata.

This study suggests that the intestinal microbiota may have protective effects against celiac disease by degrading gluten and maintaining intestinal barrier integrity, but disruptions in the microbiota can exacerbate the disease.

This study reported a rare case of ovarian steroid cell tumor removal resulting in normalized hormone levels, resumption of menstruation, and subsequent spontaneous pregnancy in a 31-year-old woman.

In this study, the combination of camouflage and psychotherapy significantly improved quality of life for vitiligo patients and potentially modulated psycho-neuro-endocrine-immune interactions.

This review found that antiseizure medications, particularly phenytoin and valproate, are associated with cosmetic side effects like gingival hyperplasia, hirsutism, acne, and hair loss.

This review discusses the psychological and emotional effects of common dermatologic conditions and highlights their impact on quality of life, but it does not present new clinical results.

This review explores the hormonal factors related to hidradenitis suppurativa, emphasizing insulin resistance and pro-inflammatory adipokines, but reports no new clinical findings and suggests further research is needed.

This review discusses the effects of calorie restriction on skin aging, highlighting its potential to benefit skin health by reducing age-related and photo-induced changes, although the impact of certain diets remains unexplored.

This review highlights emerging strategies to manage chemotherapy side effects like nausea, neuropathy, and alopecia, noting that scalp cooling has been effective for reducing hair loss, while cryotherapy and cannabis show promise but need further study for side effect management.

This review highlights recent research using single-cell RNA sequencing and machine learning in wound healing, revealing significant insights into fibroblast diversity, immune cell dynamics, and the spatial organization of cells, which may transform therapeutic strategies for chronic wounds, fibrosis, and tissue regeneration.

This review explored the biological properties of Punica granatum, noting its antioxidant, anti-inflammatory, and antimicrobial activities, and highlighted its potential as a therapeutic agent for various conditions; however, more extensive clinical trials are needed to confirm its effectiveness and safety.

This narrative review discusses the mixed and evolving evidence regarding glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and their influence on erectile dysfunction in men with type 2 diabetes and obesity, highlighting potential benefits and concerns yet to be clarified.

This study found that women with PCOS in Poland had higher anxiety and depression levels and lower ego-resiliency compared to healthy women, often using passive stress-coping strategies.

This study found that Synsepalum dulcificum seed oil hair treatment significantly reduced hair breakage and improved hair health indices in women, outperforming both placebo and argan oil treatments.

This meta-analysis found that women with polycystic ovary syndrome have over a 2.5-fold higher risk of depression compared to healthy women.

In this study, a mixed-methods survey of 357 balding men revealed that baldness is structurally stigmatized, with many participants experiencing distress and using treatments to combat it; others resisted stigma and expressed minimal distress.

This study found that school-related stress increases hair cortisol in girls and alters hair testosterone and cortisol levels in boys, indicating gender-specific hormonal responses to environmental changes.

In this study, fingertip regeneration in mice was associated with specific signaling pathways involving hair follicles and hedgehog signaling, with potential implications for improving human hand injury treatments.

This study analyzed post-marketing data from the U.S. FDA Adverse Event Reporting System and identified both known and new safety concerns for Avacopan, an anti-neutrophil cytoplasmic antibodies-associated vasculitis treatment, emphasizing the need for monitoring during early treatment stages.

This review compares DNA-derived biopolymers, PN and PDRN, in dermatology, emphasizing their distinct molecular characteristics and roles, and reports no new clinical results.

This pilot study found that a very low-carbohydrate eating pattern, combined with supportive affect and mindful eating skills, was feasible and acceptable for weight management in young women with obesity, with 50% of participants losing at least 5% of their body weight over four months.

This study found that in male mice, microglial changes due to a Parkinson's-like lesion were influenced by sex hormones, with dutasteride treatment preventing some effects.

This study developed two highly reliable Arabic HRQoL questionnaires for evaluating quality of life in married and unmarried women with polycystic ovary syndrome.

This study found that JAK inhibitors used to treat alopecia areata have varied safety profiles, with different adverse events associated with each drug; tofacitinib and ruxolitinib had earlier onset of events, while baricitinib and ritlecitinib showed distinct delayed patterns.