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Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Skin aging reflects overall body aging and can indicate internal health conditions.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

There are many ways to treat Polycystic Ovary Syndrome, including lifestyle changes, surgery, and various medications, but more research is needed for better treatments.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.

PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

PCOS may increase the risk of certain cancers.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The document concludes that careful evaluation is needed to diagnose PCOS correctly due to similar symptoms in other conditions, and accurate testosterone level measurement is crucial.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Effective treatments for excessive hair growth in women include creams, laser therapy, and medications, with the choice depending on individual needs and potential side effects.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Testosterone changes important cell communication proteins in pregnant rats' uteruses, which might affect pregnancy success.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.