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Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Plant extracts in shampoo improved hair thickness and density in men with hair loss.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Gut microbes significantly affect brain steroid levels.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Testosterone therapy can improve sexual satisfaction and mood in surgically menopausal women when used with estrogen, but its long-term safety and effects on naturally menopausal and premenopausal women are unclear.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Red clover extract improved hair, skin, mood, sleep, and tiredness in postmenopausal women.

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Finasteride can slow hair loss and promote growth in postmenopausal women.

Estradiol stops hair growth in mice, but an antagonist can reverse this effect.

Transgender females can reach their target estrogen levels using estradiol patches, especially if oral treatments fail or if they're at risk for blood clots. Often, the highest dose patch is needed.

Tiny lipid particles carrying 17-α-estradiol gather in hair follicles, which may help target alopecia treatment.

17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.

A lotion with minoxidil, hydrocortisone butyrate, and 17a-estradiol can improve or stabilize Frontal Fibrosing Alopecia in some cases, but there's no universally-accepted treatment yet.

Topical finasteride works faster and better than 17α-estradiol for postmenopausal hair loss.

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

17α-estradiol extends lifespan and improves metabolism in male mice through the estrogen receptor α.

The method detected sex hormones in some health supplements, with one containing banned testosterone.

Estrogen receptors may not affect mouse hair growth as previously thought, and oxybenzone in sunscreen is stable in sunlight.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

HPV genes and estradiol increase a cancer-related signaling pathway, which may be targeted for cervical cancer treatment.

The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

Hormone replacement therapy may lower the risk of severe COVID-19 outcomes in non-immunosuppressed people and male organ transplant recipients.

Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.