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This study demonstrated that steroidal carbamates 7–10 altered mRNA expression related to lipid metabolism in hamster flank organs and inhibited 5α-reductase activity without binding to the progesterone receptor.

This study found that ketorolac tert-butyl ester enhances skin permeation and follicular absorption compared to ketorolac, highlighting the role of lipophilicity and solubility in prodrug design.

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

This review discusses using extracellular vesicles as less invasive surrogates for assessing drug-metabolizing enzymes and transporters, suggesting potential advancements in precision therapy, but reports no new clinical results.

This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.

This study found that the n-butanol extract from Untica mairei Levl's roots significantly inhibited 5α-reductase activity in an in vitro model using rat prostate enzyme.

This study identified new oxidative derivatives of finasteride, including a newly discovered metabolite, by using the fungus Macrophomina phaseolina.

This study suggests that PRX01, PRX44, and PRX73 regulate extensin-mediated cell wall properties during root hair cell growth, influencing growth patterns, peroxidase activity, and cell wall thickness.

This study reported that certain newly synthesized steroidal derivatives showed stronger inhibitory activity against the 5α-reductase enzyme than finasteride in hamsters, suggesting their potential as enzyme inhibitors.

This study found that specific steroids, particularly 5 and 7b, decreased growth of prostate and seminal vesicles and bound to the androgen receptor, showing comparable pharmacological activity to finasteride.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

This study found that ethanol's ability to block long-term potentiation in rat hippocampal slices is influenced by neurosteroids that enhance GABA A receptor activity.

This review discusses the development and potential therapeutic applications of steroid sulfatase inhibitors for hormone-dependent disorders and cognitive dysfunction, reporting no new clinical results.

In this study, researchers found that both thermolabile and thermostable forms of phenol sulfotransferase contribute to the sulfation of minoxidil, emphasizing the need to consider both enzymes in assessing sulfation in human tissues.

This study found that some synthesized 17-oximino-5-androsten-3β-yl esters demonstrated stronger cytotoxicity and antiandrogenic activity against prostate cancer cells than finasteride.

This review examines the molecular mechanisms by which the proapoptotic protein ARTS inhibits tumorigenesis and discusses prospects for developing drugs that mimic its function, with no new experimental results reported.

This study found that distinct isoenzymes of 3 beta-hydroxysteroid dehydrogenase are expressed in human adrenals and gonads compared to the placenta and skin.

This study developed and validated a micellar electrokinetic chromatography method to determine finasteride stability, finding that the drug degrades under acidic, basic, and oxidative stress conditions.

This study found that 60% of examined prostate tumors had new somatic substitutions in the SRD5A2 gene, affecting enzyme activity and potentially influencing prostate cancer progression.

This study found that the alkaline degradation process of hair keratin using nucleophilic reagents led to different proportions of reaction products compared to wool, particularly more lanthionine and lysinoalanine residues.

This study found that a combination of spermidin, rutine, and zeaxantine effectively reduced staurosporin-induced apoptosis in cultured hair follicle dermal papilla cells, potentially preventing the regression phase in the hair follicle cycle.

This study found that miR-150 enhances the resolution ability of endothelial progenitor cells in venous thrombosis by promoting cell differentiation and proliferation through specific gene regulation pathways.

This study found that phosphodiesterase inhibitors may suppress the proliferation of benign prostatic hyperplasia epithelial cells by modulating CCL5 levels in low androgen conditions.

This study identified a sulfotransferase activity in rat liver that catalyzes the sulfation of minoxidil, contributing to its delayed hypotensive effects.

The researchers reported that disrupting ATRA signaling by deleting RDHE genes in the hair follicle led to altered hair follicle cycles, composition, and gene expression, indicating RDHEs' role in hair follicle signaling coordination.

This article discusses the enzyme pathways involved in androgenetic alopecia and the role of finasteride in reducing dihydrotestosterone levels to promote hair growth; it reports no new clinical results.

This molecular docking study reported that danoprevir, remdesivir, and saridegib exhibit stronger binding affinities to the main protease of SARS-CoV-2 than the control, suggesting their potential as inhibitors of the virus's replication process.

This invention reports piperazine derivatives as potent inhibitors of type 3 17β-hydroxysteroid dehydrogenase, suggesting potential therapeutic applications in treating prostate cancer, acne, and androgenic alopecia.