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The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Androgens may block hair growth signals, targeting this could treat hair loss.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

The new formulation improved the skin absorption of the drug Thiocolchicoside.

Finasteride doesn't affect bone density in male rats.

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

Undariopsis peterseniana extract helps hair grow by activating certain cell growth pathways and could be a new treatment for hair loss.

Daughters of women with PCOS generally experience normal puberty but may have more body hair and different body fat distribution.

Cheonggukjang may help prevent and manage various diseases and improve overall health, but its odor and safety concerns need addressing.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

Dihydrotestosterone affects hair growth by changing the Wnt/β-catenin pathway, with low levels helping and high levels hindering growth.

Alopecia areata, a type of hair loss, is likely an autoimmune disease with a genetic link, but its exact cause is still unknown.