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The researchers concluded that their new reconstructed human epidermis model from plucked hair follicle-derived keratinocytes offers a safer and simpler alternative to traditional skin-derived models for studying epidermal function.

Increased IGF-1R expression is linked to thicker skin growth.

This study developed a 3D skin model with immune and endothelial cells, which may enhance understanding of skin biology and diseases due to its closer approximation to native skin.

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

The skin is the body's largest organ, with layers, cells, and structures that protect and support it.

Keratinocyte growth factor significantly alters skin and tissue development.

This study identified epiprofin as a highly tissue-specific nuclear protein that promotes cell proliferation, mainly expressed in the developing teeth, hair follicles, and limbs of embryonic mice.

This study reports that during late embryogenesis and early postnatal development, K79-expressing keratinocytes change and die independently of sebaceous glands to form the hair follicle opening, potentially influencing conditions like ingrown hairs or acne.

This study found that epithelial keratin K 6 is associated with hyperkeratotic and ulcerated changes in the gastric pars oesophagea of pigs, suggesting epithelial proliferation plays a role in ulcer development.

Epithelial cell growth in rat hair follicles needs contact with mesenchymal cells through the extracellular matrix.

This review discusses the potential role of vascular endothelial cells as signaling niches influencing epithelial stem cell states in the skin, emphasizing the need for further exploration in this area.

This research investigated the role of EphA1 in embryonic and adult tissues, generating mouse models suggesting potential links to skin and colon cancer, sepsis, and post-traumatic injury.

This study used electron microscopy to identify a distinct dendritic cell in the human epidermis, similar to the melanocyte, with unique structural features and variable melanin content.

This review highlights that the epidermis acts as an endocrine organ, synthesizing and responding to hormones such as corticosteroids and Vitamin D, impacting processes like hair growth and immune response, and participating in regulating endocrine balance.

This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.

This study identified Sciellin, a new protein precursor to the cornified envelope in keratinocytes, with unique solubility properties hinting at its potential role in envelope assembly.

This article discusses the importance of understanding the skin's structure and function for comprehending both healthy skin biology and skin disease pathophysiology, but reports no new findings.

Human hair follicles have a unique cell distribution and differentiation pattern during growth.

This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.

This study found that mEGF ethosomal delivery systems mainly penetrated mice skin through the pilosebaceous unit and successfully induced hair follicles to transition from the telogen to anagen phase.

This study found that YAP1 localization and expression patterns in human skin xenografts resembled pathological conditions, suggesting that YAP1 may be a potential target for treating skin pathologies.

In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

This chapter reports an organ culture method that permits mouse embryonic skin tissues to develop similarly to in vivo conditions, revealing that epidermal growth factor inhibits hair follicle formation.

This study found that overexpression of Claudin 6 in mice led to incomplete epidermal formation and hair abnormalities, suggesting its crucial role in skin differentiation and hair follicle development.

This article reviews cytokeratin expression patterns in epithelial tissues and tumors, suggesting these patterns can aid in differentiating primary and metastatic carcinomas, without presenting new clinical results.

This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.

This study found that incorporating hair follicle-primed spheroids into skin constructs showed potential for developing hair-bearing skin mimetics with follicle-forming abilities in vitro.

This study found that loss of integrin-β4 or its ligand, laminin-α3β3ɣ2, in keratinocytes increases differentiation via delamination, and demonstrated a role for hemidesmosomes in epidermal differentiation through both mitotic and non-mitotic mechanisms, influenced by Notch signaling.