The Krüppel-Like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation

The study identified a cDNA clone for epiprofin, a member of the Krüppel-like factor family, which was expressed in developing teeth, hair follicles, and limb buds of embryonic mice. Epiprofin mRNA was found in proliferating dental epithelium, differentiated odontoblasts, and hair follicle matrix epithelium, with transient expression in developing limb cells. The research demonstrated that epiprofin is a nuclear protein promoting cell proliferation, suggesting its role in tissue development by regulating cell growth.