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    Glossary Epidermal Necrosis

    death of outer skin cells causing discoloration and peeling

    Epidermal necrosis refers to the death of cells in the outermost layer of the skin, known as the epidermis. This condition can result from various causes, including severe infections, burns, or adverse reactions to medications, leading to symptoms like skin discoloration, blistering, and peeling. For professionals, it is crucial to identify the underlying cause to provide appropriate treatment and prevent further tissue damage.

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    1. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    2. Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice 2023
    3. Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice 2023
    4. Cutaneous necrosis after injection of polyethylene glycol–modified interferon alfa Journal of The American Academy of Dermatology · 2005 · 26 citations
    5. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    6. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    7. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization Stem Cell Research & Therapy · 2020 · 65 citations
    8. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    9. Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation Experimental Dermatology · 2015 · 12 citations
    10. The Tumor Necrosis Factor-α Level in Platelet-Rich Plasma Might Be Associated with Treatment Outcome in Patients with Interstitial Cystitis/Bladder Pain Syndrome or Recurrent Urinary Tract Infection International Journal of Molecular Sciences · 2023 · 8 citations
    11. Supplementary material for: Microinjury-Induced Tumor Necrosis Factor-α Surge Stimulates Hair Regeneration in Mice Figshare · 2023
    12. Toxic epidermal necrolysis caused by etonogestrel implantation: A rare presentation JAAD case reports · 2022 · 1 citations
    13. Aseptic Necrosis of Warts Instead of Lymphangitis Archives of Dermatology · 1976
    14. Aseptic Necrosis of Warts Instead of Lymphangitis-Reply Archives of Dermatology · 1976
    15. Clinical, histopathologic, immunohistochemical, and electron microscopic findings in cutaneous monkeypox: A multicenter retrospective case series in Spain Journal of the American Academy of Dermatology · 2022 · 26 citations
    16. The early changes in mouse skin following topical application of a range of middle distillate oil products Journal of Applied Toxicology · 1993 · 19 citations
    17. Der Einfluβ des experimentellen Biotinmangels auf Morphologie und Histochemie von Haut und Klauen des Schweines Zentralblatt für Veterinärmedizin Reihe A · 1984 · 9 citations
    18. Monkeypox: A Histopathological and Transmission Electron Microscopy Study Microorganisms · 2023 · 5 citations
    19. Lucio Phenomenon mimicking with Vasculo necrotic Erithema Nodosum Leprosum: A Case Report International Journal of PharmTech Research · 2020
    20. 977 The wound healing of fractional photothermolysis mimicks scarless healing with minimal myofibroblast activation Journal of Investigative Dermatology · 2019
    21. Dose-Dependent Histopathological and Structural Impact of Chemical Hair-Straighteners on Scalp Epithelium and Hair-Fibres Using Albino Wistar Rats Sahel Journal of Life Sciences FUDMA · 2025
    22. Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata Archives of Dermatological Research · 1996 · 91 citations
    23. Animal Study of Skin Resurfacing Using the Ultrapulse Carbon Dioxide Laser Annals of Plastic Surgery · 1995 · 69 citations
    24. An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB/c Mice International journal of toxicology · 2015 · 36 citations
    25. Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth International Journal of Dermatology · 2001 · 27 citations
    26. Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype Journal of Cell Science · 1994 · 25 citations
    27. 1 The regulatory biology of the human pilosebaceous unit Baillière's clinical obstetrics and gynaecology · 1997 · 17 citations
    28. Androgen receptor–mediated inhibition of cutaneous wound healing 2002 · 9 citations
    29. Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model Journal of Microbiology and Biotechnology · 2024 · 3 citations
    30. Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition PLoS ONE · 2021 · 3 citations