Generalized Cutaneous Necrosis: A Complication of Low-Molecular-Weight Heparin

September 2005 in “ International Wound Journal ”

Girish Khandubhai Patel, Arthur Knight

cutaneous necrosis low-molecular-weight heparin tinzaparin deep vein thrombosis heparin necrosis skin biopsy thrombophilia heparin injections histopathological findings nutritional supplements topical dressings surgical debridement skin grafts antibody-mediated thrombocytopenia LMWH DVT

TLDR A woman developed severe skin damage after using a blood thinner called low-molecular-weight heparin.

The document describes a case where a 66-year-old woman developed generalized cutaneous necrosis after being treated with low-molecular-weight heparin (LMWH), specifically tinzaparin, for a suspected deep vein thrombosis (DVT). Despite normal blood count and thrombophilia screen results, a skin biopsy confirmed the diagnosis of heparin necrosis based on the timing of heparin injections, skin symptoms, rapid progression, and histopathological findings. The patient's treatment included nutritional supplements, topical dressings, surgical debridement, and skin grafts. The case highlights the need for awareness of heparin necrosis, which can be fatal and is more common in certain adult populations. The exact cause of heparin necrosis remains unclear, but it may be related to antibody-mediated thrombocytopenia.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 12 results

community How do you use rosemary oil and peppermint oil?

in Question 6 upvotes 4 years ago

Rosemary oil and peppermint oil may promote hair growth and increase cutaneous blood flow, showing promise as treatments for androgenetic alopecia. Minoxidil 2% is also used for treating hair loss.

community Scientific evidence for Peppermint & Rosemary oils + My Experience

in Research/Science 114 upvotes 1 year ago

Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

community high bloodpressure and crown thinning in early 20s

in Is this regrowth? 9 upvotes 5 months ago

A user with kidney disease and high blood pressure experienced hair thinning, especially around the vertex. They are currently using finasteride and oral minoxidil but are considering whether to resume blood pressure medication despite managing symptoms with diet and exercise.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

in Research/Science 108 upvotes 1 year ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Why is everyone not directly advised Dutasteride?

in Finasteride/Dutasteride 165 upvotes 1 month ago

Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.