research Pharmacotherapy for Keloids and Hypertrophic Scars
Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.
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research Overweight and Obesity in Children and Adolescents
Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.
research Clinical Manifestations of Alopecia in Autoimmune Blistering Diseases: A Cross-Sectional Study
Most patients with autoimmune blistering diseases experienced some hair loss, which may be underreported and linked to disease severity.
research Dermatological Changes During Menopause and HRT: What to Expect
Menopause worsens skin, hair, and nails, affecting self-esteem and quality of life.
research Transgenerational Transmission of Reproductive and Metabolic Dysfunction in Male Progeny of Polycystic Ovary Syndrome
Sons of mothers with polycystic ovary syndrome (PCOS) have a higher risk of obesity and insulin resistance, possibly due to certain genes and factors passed down from their mothers.
research Novel Cosmeceuticals from Plants: An Industry-Guided Review
Plant-based ingredients are effective and safe for modern skincare products.
research Maternal Melatonin Contributes to Offspring Hair Follicle Development Through Transcriptional Regulation of the AP-1 Complex and MAPK Pathway
The study examines the impact of maternal melatonin (MT) on hair follicle (HF) development in rabbit offspring, revealing that MT enhances HF density and reduces HF cell apoptosis. This effect is mediated through the transcriptional regulation of the AP-1 complex and the MAPK signaling pathway, with significant roles played by the JUN and FOS proteins. MT administration leads to the downregulation of JUN/FOS and AP-1, while affecting metabolites like equol and norepinephrine, crucial for HF development. The study suggests that MT crosses the placental barrier, influencing fetal skin and HF development, and highlights the potential of MT signaling pathways as therapeutic targets for HF-related conditions. Further research is needed to confirm these findings and explore therapeutic applications.
research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program
The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.
research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.
research Application of Mesenchymal Stem Cells for Anti-Senescence and Clinical Challenges
Mesenchymal stem cells could help treat aging-related diseases better than current methods.
research Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia
Finasteride slightly better long-term, minoxidil faster initial results, but stopping minoxidil may cause hair loss.
research Rhodococcus Equi: Clinical Manifestations, Virulence, and Immunity
Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.
research Mechanisms of Impairment in Hair and Scalp Induced by Hair Dyeing and Perming and Potential Interventions
Hair dyes and perms can damage hair and scalp, but using interventions can reduce harm.
research Complications of Cushing's Syndrome: State of the Art
Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.
research Is Autologous Platelet-Rich Plasma Capable of Increasing Hair Density in Patients with Androgenic Alopecia? A Systematic Review and Meta-Analysis of Randomized Clinical Trials
PRP injections can increase hair density in people with androgenic alopecia.
research The Clinical Spectrum of Parathyroid Disease
The document concludes that parathyroid diseases have a range of clinical features and outcomes, with some conditions being treatable and others having a high risk of mortality.
research Artificial Hair Implantation for Hair Restoration
Artificial hair implants can quickly improve looks and life quality, but they have risks like infection and early fiber loss, so more research is needed to confirm their safety and effectiveness.
research The Additive Value of Platelet-Rich Plasma to Topical Minoxidil in the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis
Combining PRP with Minoxidil improves hair density and thickness more than Minoxidil alone.
research Dermal Papilla Cells and Melanocytes Response to Physiological Oxygen Levels Depends on Their Interactions
Low oxygen levels improve the function of hair and skin cells when they are in direct contact.
research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp
Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
research Expression of Mesenchymal Stem Cell Marker CD90 on Dermal Sheath Cells of the Anagen Hair Follicle in Canine Species
CD90 is present on specific cells in dog hair follicles.
research Adipose-Derived Stem/Stromal Cells in Regenerative Medicine
Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.
research Primary Cicatricial Alopecias
Early diagnosis and aggressive treatment are key for managing rare scalp disorders that cause permanent hair loss.
research Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles
The document describes a way to isolate and grow human hair follicle cells in 3D to help study hair growth.
research Investigation of Glypican-4 and -6 by Infrared Spectral Imaging During the Hair Growth Cycle
Infrared spectral imaging can effectively study protein distribution in hair follicles during hair growth.
research Morphological Analysis of Patchy Thickening and Reddish Discoloration of Active Hair Growth Areas in the Skin of New Zealand White Rabbits
Rabbit skin with active hair growth shows thicker, redder areas due to larger, more numerous hair follicles and increased blood vessels.
research Disruption of the Temporally Regulated Cloaca Endodermal β-Catenin Signaling Causes Anorectal Malformations
Disrupting β-catenin signaling in certain cells causes anorectal malformations.
research Treatment of Hirsutism with 5α-Reductase Inhibitors
New compounds may soon be tested to treat excessive hair growth in women.
research New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-Depth Review of the Literature
There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.
research PH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption
Keratin structure in hair is stable at pH 5-6 but disrupts between pH 6-7.