321 citations
,
March 2015 in “Nature” This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.
245 citations
,
January 2018 in “Bone Research” This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.
182 citations
,
November 2017 in “Molecular Aspects of Medicine” This review discusses various therapeutic strategies targeting platelet-derived growth factor signaling in diseases like cancer and atherosclerosis, and evaluates existing treatments without presenting new clinical data.
173 citations
,
January 2014 in “Nature Cell Biology” This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.
144 citations
,
August 2019 in “Cells” This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.
133 citations
,
February 2019 in “PLoS Biology” This research found that feather pattern formation in birds is regulated by a mechanochemical system involving fibroblast growth factor and bone morphogenetic protein signaling, which is altered in the flightless emu and ostrich.
108 citations
,
November 2006 in “The Milbank Quarterly” This article reviews the history and impacts of direct-to-consumer advertising of prescription drugs in the U.S. and reports no new research findings; it discusses implications for health policy debates.
103 citations
,
March 2011 in “PLoS Biology” This study found that a mutation in the BMP12/GDF7 gene is associated with the Naked neck trait in chickens, reducing neck feathering due to altered signaling pathways.
88 citations
,
July 2008 in “Development” This study shows that BMP2 and BMP7 play complex, necessary roles in feather development by regulating dermal condensation formation, with BMP7 acting early as a chemoattractant and BMP2 halting cell migration.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
81 citations
,
January 2003 in “The FASEB Journal” This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.
75 citations
,
March 2014 in “Journal of Investigative Dermatology” This study found that aging mice experience slower and more fragmented hair cycle waves, but transplanting aged skin to a young host can partially restore hair cycling, implicating extracellular factors.
71 citations
,
February 2020 in “Journal of Translational Medicine” This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.
26 citations
,
April 2019 in “Genes” In this study, researchers identified novel long non-coding RNAs related to cashmere fineness in goats, highlighting a potential regulatory network involving lncRNA XLOC_008679 and its target gene KRT35.
25 citations
,
September 2020 in “Molecules” In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.
25 citations
,
February 2019 in “Genomics” This study reports that milk goats exhibit significantly more differentially expressed genes related to hair follicle cycling across different months compared to cashmere goats, especially in December.
25 citations
,
September 2014 in “Biological Research” This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.
22 citations
,
May 2021 in “Nature Communications” This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.
19 citations
,
April 2015 in “European Journal of Pharmacology” This study found that dihydrotestosterone (DHT) may shorten the hair growth cycle through mechanisms like cell-cycle arrest and β-catenin downregulation in rat hair follicle cells.
17 citations
,
August 2018 in “BMC Genomics” The researchers found that HOXC13 regulates different keratin proteins in a mixed manner, with certain SNPs impeding this regulation, while also demonstrating negative-feedback by HOXC13 and positive regulation by LEF1 and melatonin on the HOXC13 promoter.
16 citations
,
January 2005 in “The International Journal of Developmental Biology” This study found that Hex gene expression patterns in chick embryo dorsal skin during feather bud development suggest a significant role in initiating feather morphogenesis.
13 citations
,
September 2024 in “Frontiers in Pharmacology” This review highlighted the pharmacological potential of Mor, noting its protective effects on the kidneys, liver, bones, nervous system, heart, digestive system, skin, and lungs, as well as its anti-obesity and anti-inflammatory properties, revealing areas for future research.
12 citations
,
February 2025 in “Scientific Reports” This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.
12 citations
,
February 2021 in “Translational Psychiatry” This study identified two novel genetic variants associated with Alzheimer's disease in APOE ε4 non-carriers, revealing insights into the disease's underlying regulatory mechanisms.
10 citations
,
November 2022 in “Protein & Cell” In this study, topical quercetin was found to stimulate hair follicle growth and promote microvascular regrowth in mice, suggesting its potential for hair regrowth strategies.
10 citations
,
May 2012 in “Cell Adhesion & Migration” This study found that ILK/ELMO2 complexes in epidermal keratinocytes are selectively activated by epidermal growth factor to induce cell migration, unlike with other growth factors.
9 citations
,
August 2024 in “Tissue Engineering and Regenerative Medicine” In this study, researchers suggest that strategic early intervention during fetal wound healing could lead to significantly improved long-term skin regeneration outcomes.
9 citations
,
January 2021 in “RSC Advances” Non-thermal plasma helps hair grow by improving the area around hair follicles.
8 citations
,
October 2023 in “Folia Histochemica et Cytobiologica” This study observed that exosomes from adipose mesenchymal stem cells overexpressing hepatocyte growth factor significantly improved liver function and reduced fibrosis in mice with experimentally induced liver injury.
7 citations
,
June 2022 in “Czech Journal of Animal Science” This study identified 21 novel circular RNAs in cashmere goats, with nine significantly more expressed during the anagen phase of hair follicle growth, suggesting roles in hair regeneration and cashmere yield enhancement.