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research Image3_Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and drug−gene Interaction Network.TIFF
This study found a significant association between montelukast and neuropsychiatric adverse events such as suicidal ideation and depression, suggesting that the drug's interaction with specific genes may contribute to these effects.
research FDA declines approval of testosterone drug for third time
This report discusses the FDA's third denial of approval for Aveed, a long-acting testosterone injection by Endo Pharmaceuticals, citing continued safety concerns including severe side effects.
research Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer
Using a niacinamide cream can improve life quality for breast cancer patients during chemotherapy.
research P0881 Effectiveness and Safety of Tofacitinib in Biologic-Naïve Elderly Patients with Ulcerative Colitis
In this study, tofacitinib showed promising efficacy and safety for biologic-naïve elderly patients with moderate-to-severe ulcerative colitis, achieving steroid-free remission and clinical response over 52 weeks.
research 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells
This study identified a specific subset of macrophages as a key source of oncostatin M, maintaining hair follicle stem cell quiescence during the resting phase in mice, suggesting a potential target for treating hair disorders.
research Antibacterials/corticosteroids/minoxidil
research Inositol and FSH: A new frontier for the androgenetic alopecia treatment
This study reports a significant reduction in hair loss and other androgen-related signs in hyperandrogenism patients using inositol supplementation, although further research is needed to confirm these findings.
research P273 : Recalcitrant alopecia areata improved with intralesional polydeoxyribonucleotide injection: two case reports
This study reports significant hair regrowth in two alopecia areata patients resistant to intralesional corticosteroids after treatment with intralesional polydeoxyribonucleotide.
research Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations
This study found that constitutively active Stat3 in transgenic mice led to reduced keratinocyte stem cell populations in hair follicles, altering stem/progenitor cell dynamics and homeostasis.
research Konvergentna validacija farmakoekonomskih aspekata terapije benigne hiperplazije prostate u Crnoj Gori
This study found that dutasteride is more cost-effective compared to finasteride for treating benign prostatic hyperplasia in Montenegro, justifying its funding by the national health insurance fund.
research Impact of ustekinumab on quality of life and sexual difficulties associated with psoriasis: Results from phase III clinical trials
This study found that nonobese women with idiopathic hirsutism exhibited lower nitrite/nitrate concentrations and higher fibrinogen levels compared to control subjects, but these were similar to levels in women with polycystic ovary syndrome.
research Calcipotriene plus betamethasone dipropionate gel: a new combination therapy for scalp psoriasis
This study found that the once-daily gel combining calcipotriene and betamethasone dipropionate was more effective and faster in treating scalp psoriasis compared to individual treatments, with a similar safety profile.
research Nucleus‐specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus
This study found that the 5α-reductase inhibitor finasteride affected phasic and tonic GABA A receptor-mediated currents differently in the thalamic reticular and ventrobasal nuclei of mice, suggesting endogenous neurosteroid modulation of these receptors.
research Molecular Docking Studies and ADME Prediction of Novel Isatin Analogs with Potent Anti-EGFR Activity
This study conducted molecular docking and ADME property analysis on 144 newly designed isatin analogs, suggesting they exhibit lead-like properties for targeting EGFR enzymes.
research Development and Invitro Evaluation of Solid Lipid Nano Particles Loaded Topical Gel Containing Combination of Drugs Used In The Better Therapy of Psoriasis
This study reported that a solid lipid nanoparticle-based gel formulation, specifically optimized for psoriasis, improved drug loading capacity and release properties using high-pressure homogenization, suggesting its potential efficacy as a topical treatment.
research Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus
In this study, researchers found that after reducing GABAergic inhibition in rats' auditory midbrain, the brain quickly compensates by increasing local neurosteroid synthesis to maintain balance in neural circuits.
research Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress
In this study, finasteride was found to potentiate stress-induced disruption in sensory gating of rats by neutralizing the increase in allopregnanolone levels after acute stress.
research Alopecia Universalis Treated With Tofacitinib: The Role of JAK/STAT Inhibitors in Hair Regrowth
This case report presented the successful treatment of a patient with alopecia universalis using tofacitinib.
research Antiulcer drugs
The document concludes that H2-antagonists and proton pump inhibitors are highly effective for ulcers, eradicating Helicobacter pylori is important to prevent recurrence, and misoprostol helps with NSAID-related ulcers.
research β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress
In this study, NMN was found to reverse hair follicle atrophy, thinning, and sparsity in mice induced by DHT, and significantly decreased DHT-induced inflammation and oxidative stress in cultured human dermal papilla cells, enhancing hair growth-related markers.
research Coregulation of Genetic Programs by the Transcription Factors NFIB and STAT5
This study suggests that NFIB and STAT5 work together to control cell-specific genetic programs in mammalian tissues, particularly in mammary and hair follicle stem cells.
research 1492 Prostacyclin pathway to enhance wound healing in diabetic foot ulcers
This study found that treprostinil, a prostacyclin analog, significantly delayed fibroblast migration from healthy donors but did not affect fibroblast migration derived from diabetic foot ulcers.
research Lactium: A Novel Drug for Psychocutaneous Skin Disorders
Lactium, a milk protein, can help reduce symptoms of skin disorders linked to stress and anxiety without side effects.
research Effect of tofacitinib on the expression of noggin/BMP-4 and hair growth stimulation in mice
The researchers reported that topical tofacitinib in mice increased hair follicles in the growth phase and boosted noggin and BMP4 mRNA expressions, compared to a vehicle and minoxidil.
research 1048 Treatment of nodulocystic acne with once weekly finasteride: A pilot study
This study suggests that weekly oral finasteride may be a promising alternative to isotretinoin for treating nodulocystic acne, showing substantial improvements with lower incidence of sexual dysfunction.
research Impact of Cernitin™ on induced chronic prostatitis in animal model for understanding management of lower urinary tract symptoms
This study in male rats found that Cernitin™ significantly relieved pain and decreased prostate weight in models of chronic prostatitis and benign prostatic hyperplasia, suggesting an anti-inflammatory effect.