Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and Drug-Gene Interaction Network

The study analyzed data from the FDA Adverse Event Reporting System from 2004 to 2018 to investigate the link between montelukast, a medication for asthma and allergies, and neuropsychiatric adverse events. It found significant associations, with reporting odds ratios of 21.5 for suicidal ideation and 8.2 for depression. The research identified 1,144 human genes interacting with montelukast, with functional analysis revealing significant enrichment in neuroactive ligand-receptor interactions and associations with mood disorders and major depressive disorder. The findings highlighted the need for further research into the pharmacological mechanisms behind these neuropsychiatric effects.