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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Melatonin protects skin against UV damage by regulating various cellular processes.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

Thymosin β4 helps improve skin healing and reduce scarring.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Obesity worsens Polycystic Ovary Syndrome symptoms, and weight loss is a key treatment.

Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.

Tannic acid helps wounds heal faster in rats by activating certain cell signals and reducing inflammation.

lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Taking spironolactone and linestrenol for androgen excess can lead to lower bone density in young women.

Herbal products might promote hair growth with fewer side effects, but more research is needed to confirm their safety and effectiveness.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Hedgehog signaling is crucial for mammary gland development over hair follicles.