Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that sodium valproate significantly reduced seizure frequency by over 50% in about 70% of patients with generalized seizures but was less effective for partial seizures.

This case report describes a postmenopausal woman who experienced facial erythema, acne, and hirsutism due to excess androgen and estrogen levels.

This case report details a fixed-drug eruption in a woman linked to the use of dextromethorphan, marking it as a previously unreported skin reaction to this medication.

This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.

This study found that boosting the synthesis of neural-derived 17β-estradiol effectively counteracted the impairment of hippocampal long-term potentiation caused by amyloid beta 1-42 in rat hippocampal slices, with the effect seemingly linked to glutamate NMDAR signaling.

This study found that ethionine significantly inhibited wool growth in sheep, with L- and D-isomers being equally effective, but did not cause hair loss in sucking mice or rats.

In this study, IFN-γ-stimulated iPSC-derived mesenchymal stem cell extracellular vesicles improved atopic dermatitis in mice by reducing Th2 cytokine activity, suppressing inflammation, and restoring skin barrier function, as evidenced by decreased itching and inflammatory markers.

This study observed that Icariside II, an extract from Epimedium brevicornu Maxim, can inhibit the growth of gastric cancer in cell lines and mouse models by promoting apoptosis and suppressing the Wnt/β-catenin signaling pathway, with minimal toxicity to normal gastric cells.

This study suggests that topical corticosteroids, potentially combined with oral zinc and followed by topical calcineurin inhibitors, may be effective for managing erosive pustular dermatosis of the scalp.

This study reported that the combination of a 308-nm excimer lamp and 10% liquor carbonis detergens significantly improved scalp psoriasis symptoms compared to the excimer lamp alone, with more patients achieving 75% reduction in their Psoriasis Scalp Severity Index.

The study concluded that poly(propylene carbonate maleate) microspheres effectively encapsulated finasteride, achieving a biphasic release with prolonged drug release over 5-6 weeks in vitro.

In this study, sustained-release sodium valproate showed high efficacy in achieving seizure remission for adults with focal and generalized epilepsy over one year, but side effects like weight gain and tremor were more frequent among heterozygous carriers of certain gene variants.

This study concluded that etretinate showed only moderate effects in treating lichen sclerosus and localized scleroderma, with some patients experiencing clearing but others having no resolution or lesion progression.

This study found that certain fatty acids and triterpenoid-glycosides from Eclipta prostrata L. leaves exhibit potent inhibitory effects on the protein tyrosine phosphatase 1B enzyme, suggesting potential anti-diabetic and anti-obesity benefits.

The authors reported that electrochemotherapy and electroporation-based treatments, both with and without cytotoxic drugs, show promise as safer and more effective options for breast cancer treatment, including metastatic cases and palliative care, in vitro and in vivo.

This letter highlights that septicemia or bacteremic shock can be a complication of enemas in elderly men with prostate infections.

This study examines how conditions like PSSD, Long COVID, and ME/CFS form a "Post-Exposure Syndromes" family, initiated by transient exposures but persisting due to complex state-space dynamics, and suggests improving pharmacovigilance to better address and understand these persistent syndromes.

In this study, patient-reported outcomes indicated that greater weight loss with GLP-1RA treatments was associated with increased reports of adverse cosmetic effects such as skin laxity, facial volume loss, and hair shedding, despite improvements in some preexisting inflammatory skin conditions.

This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.

This article discusses immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis, introducing a new quantitative method, but reports no new experimental results.

This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.

This case report suggests that topical tacrolimus may effectively manage erosive pustular dermatosis of the scalp and reverse skin atrophy, although long-term use requires monitoring for side effects.

This case report describes a rare occurrence of injection site reactions in a 77-year-old woman with eosinophilic fasciitis using subcutaneous methotrexate, marking the first documented instance in this patient population.

In this study, nifedipine provided rapid symptomatic relief in most patients with severe recalcitrant perniosis, but some experienced side effects that limited dosage and two patients were lost to follow-up.

This study found that a single 2 ml injection of TEEV every 4 weeks offers similar beneficial effects with fewer side effects compared to injecting the same dose every 2 weeks in postmenopausal women.

This report details a case of a 43-year-old woman developing yellowish papular eruptions alongside typical acneiform skin reactions on her cheeks and chest following a switch from cetuximab to panitumumab treatment.

This study found that applying ivermectin 1% cream significantly improved both visible symptoms like erythema and invisible symptoms such as stinging, burning, and dryness in rosacea patients over a period of at least 16 weeks.

This study emphasizes that erosive pustular dermatosis of the scalp is an underrecognized condition, and increased awareness and diagnosis can improve patient outcomes by preventing further scalp damage.

In this study, ethosomes were found to improve the skin penetration of a model lipophilic drug more effectively than liposomes or hydroethanolic solutions, suggesting a unique mechanism involving the breakdown of vesicles in the skin.