Icariside II Inhibits Gastric Cancer Progression by Suppressing the Wnt/β-Catenin Signaling Pathway

    May 2025 in “ Cytotechnology ”
    Rongrong Dou, Xiaowei Zhu, Xinyun Liu … Yifei Liu
    Studysummary This study observed that Icariside II, an extract from Epimedium brevicornu Maxim, can inhibit the growth of gastric cancer in cell lines and mouse models by promoting apoptosis and suppressing the Wnt/β-catenin signaling pathway, with minimal toxicity to normal gastric cells.
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    Research cited in this study 3

    1. KY19382 Accelerates Cutaneous Wound Healing Via Activation Of The Wnt/β-Catenin Signaling Pathway International Journal of Molecular Sciences · 2023
    2. Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities Signal Transduction and Targeted Therapy · 2022
    3. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021