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The researchers developed semi-dissolving microneedle patches using TEMPO-oxidized bacterial cellulose nanofibers, which allow effective transdermal drug delivery by forming micro-channels for large drug quantities, overcoming traditional microneedles' low drug loading.

This study reports that an electrochemical biosensor using a gold and palladium-modified electrode effectively detects levodopa and uric acid in various samples, offering improved performance over previous electrodes.

This review highlights that while nanoparticle-loaded dissolving microneedles have considerable promise for enhancing transdermal drug delivery, progress is delayed by insufficient understanding of their in vivo behavior, which the authors emphasize as crucial for advancing clinical applications.

This study confirmed that microneedle therapy systems (MTS) significantly improve hair growth and skin conditions, including acne and acne scars, without serious side effects.

In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

This review discusses recent advancements in microneedle technology for hair loss treatment, highlighting their ability to enhance drug delivery and improve hair follicle survival in transplantation, while also exploring their potential integration with tissue engineering to address regeneration challenges.

This review article summarizes potential side effects of microneedle mesotherapy, including both infectious and non-infectious complications such as bruises, swelling, anaphylaxis, and skin necrosis, emphasizing that awareness and proper technique may mitigate these risks.

This paper reviews the use of microneedling alone and in combination with platelet-rich plasma for various skin conditions, but it reports no new clinical findings.

This study explored the use of microneedling for dermatological disorders, highlighting its benefits like increased collagen and elastin production, dermal thickening, and skin rejuvenation, making it suitable for conditions such as scars, stretch marks, and photoaged skin.

This study developed a grooved microneedle platform enabling precise transdermal delivery of triamcinolone acetonide for alopecia areata, achieving accurate dosing by controlling groove position and drug concentration.

This study found that microbotox, especially when injected intradermally, effectively reduces enlarged facial pores with higher patient satisfaction and longer-lasting results compared to its topical application after microneedling.

This systematic review explored the feasibility of adding skin needling to an aesthetic clinic's offerings, examining financial implications, time investment, and its integration with existing treatments. Various challenges and learning opportunities were noted, underscoring the complexity of introducing a new service.

This study suggests that microneedling may be an effective and less painful treatment for vitiligo, offering benefits over traditional needle injections, particularly in challenging-to-treat areas like the extremities or stubborn regions.

A new microneedle system may improve hair loss treatment by delivering ketoconazole directly to hair follicles.

This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.

PLGA-based microneedles show promise for painless, long-term drug delivery but need design and safety improvements.

This study found that a dissolvable microneedle device delivering rapamycin and epigallocatechin gallate nanoparticles significantly enhanced hair regrowth in C57BL/6 mice within 7 days, demonstrating increased hair shaft growth and follicle density with minimal inflammation compared to untreated mice.

This narrative review compiled evidence suggesting that microneedling can effectively and safely improve skin conditions like scars, hyperpigmentation, and aging, provided it is performed correctly, by stimulating collagen production and enhancing topical treatment penetration.

This review reports that microneedle-mediated transdermal drug delivery systems show promise in enhancing alopecia treatments by improving the efficacy of various therapeutic agents, including drugs, biologics, and stem cells, but highlights a gap between basic research advancements and clinical trial focus.

This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.

This study explored the potential of silk fibroin methacrylate hydrogel microneedles to deliver α-MSH directly to the epidermis in vitiligo patients, enhancing melanocyte protection and melanosome transfer, potentially offering a new treatment avenue for this challenging condition.

This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

This review discusses the use of microneedling with a dermaroller for treating acne scars, hair loss, and wrinkles, and reports no new clinical results.

This study found that cedrol-loaded dissolvable microneedles efficiently delivered cedrol to the deep dermis, effectively promoting hair growth in C57BL/6 mice, suggesting a promising strategy for treating hair loss.

This study developed a spring-driven microneedle booster that improved early and cumulative delivery of minoxidil, accelerating hair regrowth compared to traditional roller methods in an androgenetic alopecia model.

This preclinical study found that a machine-learning-driven strategy for fabricating microneedles with optimal hardness and rapid dissolution significantly promoted hair regrowth in androgenetic alopecia mice by activating the Wnt/β-catenin pathway, surpassing the effects of minoxidil.