131 citations
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November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that alopecia areata can be induced and serially transferred in C3H/HeJ mice using skin grafts, providing a useful model for studying the disease in humans.
120 citations
,
November 2014 in “Biological Reviews” This article explores the dynamic and energy-efficient nature of telogen hair follicles, challenging the notion of dormancy, and highlights their potential in advancing treatments for hair growth disorders.
119 citations
,
June 2005 in “Journal of Molecular and Cellular Cardiology” This article reviews the therapeutic potential of potassium channel openers for various conditions related to metabolic distress but does not report new clinical results; it emphasizes the need for further research.
106 citations
,
April 2010 in “ACS Nano” This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.
98 citations
,
February 2007 in “Seminars in Cell & Developmental Biology” This review explores the hormonal regulation of hair growth and changes with season, age, and sexual development, and calls for improved treatments for hair disorders.
96 citations
,
December 2022 in “Pneumologie” This guideline review discusses current symptoms, diagnostic approaches, and treatments for Long- and Post-COVID, based on today's knowledge, and emphasizes its practical application with ongoing updates as new insights emerge.
94 citations
,
June 2016 in “The FASEB Journal” This review discusses the dual role of the Wnt/β-catenin pathway in mammalian tissue injury, highlighting its potential for both promoting regeneration and contributing to fibrosis, but presents no new findings.
92 citations
,
November 2003 in “The Journals of Gerontology” This study indicated that while testosterone replacement in older men with low testosterone increases muscle mass and strength and reduces fat, its effects on physical function, disability, falls, or fractures remain unclear.
87 citations
,
March 2005 in “Journal of Dermatological Science” This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.
86 citations
,
February 2009 in “Journal of Neuroscience” This study found that during late pregnancy in rats, there is an increase in extrasynaptic GABA A receptor number in granule cells of the dentate gyrus, linked to hormonal fluctuations.
86 citations
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February 2003 in “Journal of The American Academy of Dermatology” This article discusses various mechanisms for promoting hair growth in pattern hair loss and highlights the challenge of balancing short-term measurable results in trials with the need for long-term efficacy data.
85 citations
,
May 2019 in “Journal of neuroendocrinology” This review examines the neuroendocrine mechanisms underlying seasonal changes in mammals and highlights areas needing further research, reporting no new experimental results.
83 citations
,
March 2015 in “International Journal of Dermatology” This retrospective study found that adipose-derived stem cell-conditioned media increased hair density and thickness in women with female pattern hair loss over 12 weeks, with no severe adverse effects reported.
82 citations
,
May 2009 in “Development” This study found that downregulation of EGF and KGF signaling is necessary for hair follicle initiation in placodes, revealing a new role for KGF in hair follicle formation in mice.
81 citations
,
December 2009 in “Journal of Dermatological Science” This review discusses the paracrine effects of adipose tissue-derived stem cells on surrounding cells and tissues, noting their potential therapeutic benefits, but reports no new clinical results.
78 citations
,
October 2012 in “Biomaterials” This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.
78 citations
,
August 2002 in “Experimental Dermatology” This study describes a simplified method for isolating and cultivating human hair follicle papillae that can be easily executed by new lab personnel.
77 citations
,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.
76 citations
,
January 2017 in “World Journal of Stem Cells” This review discusses the potential applications of adipose-derived stromal cells for treating conditions like colitis, liver failure, and more, without presenting new clinical results.
73 citations
,
March 2014 in “Journal of The American Academy of Dermatology” Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.
71 citations
,
May 2007 in “The FASEB journal” This study found that human hair follicles express erythropoietin and its receptor, suggesting these follicles may use erythropoietin signaling to modulate apoptosis under stress conditions like hypoxia and chemotherapy.
70 citations
,
August 2020 in “Nanomaterials” This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.
70 citations
,
June 2017 in “Nature Communications” This study introduced a new technique, 2Phatal, enabling precise apoptotic cell ablation in living animals, revealing unique cell-type differences in apoptosis-related dynamics.
65 citations
,
September 2017 in “British Journal of Cancer” In this large British study, prostate cancer risk was linked to ethnicity, family history, prostate enlargement, and PSA testing, while excess adiposity, smoking, diabetes, and certain lifestyle factors were associated with a reduced risk.
65 citations
,
January 2005 in “American journal of clinical dermatology” This article reviews the diagnosis and treatment of tinea capitis in children, noting that newer antifungal agents can offer effective systemic therapy alongside supportive topical treatments; it reports no new clinical findings.
64 citations
,
August 2013 in “Mayo Clinic Proceedings” This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.
63 citations
,
September 2009 in “Regenerative Medicine” This study developed a method for expanding human dermal papilla cells in vitro while maintaining their ability to induce hair growth, advancing the potential for follicular cell implantation as a treatment for hair loss.
62 citations
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February 2016 in “ACS Applied Materials & Interfaces” This study found that 3D microtissue models of dermal papilla cells can enhance the ability to induce hair-follicle neogenesis in vivo, offering potential for controlled cell production in follicle regeneration.
62 citations
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July 1993 in “Journal of Investigative Dermatology” Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
60 citations
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January 2014 in “Anais Brasileiros De Dermatologia” This article discusses the foundational concepts of nanotechnology and its contributions to dermatology and medicine, but does not present new research findings.