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This study observed that cathepsin L and transglutaminase 3 colocalize in the human hair bulb and nail matrix, suggesting their involvement in terminal differentiation within these epidermal appendages.

EF and PXE not closely related.

This study found that matriptase, a membrane serine protease, is crucial for maintaining multiple types of epithelial tissues in mice, with its absence leading to severe organ dysfunction and increased permeability.

This study reports that human epidermal transglutaminase activity increases with treatment using organic solvents and chemicals without significant molecular weight changes, which may allow modulation of the enzyme in skin diseases.

This study found that specific enzymes could be detected in fresh hair sheath cells, with most remaining detectable in older cells, except for Adenylate kinase and Esterase D.

This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.

Balanced protease activity is crucial for healthy skin and hair development.

This study found that patients with Stevens-Johnson syndrome and toxic epidermal necrolysis exhibit lower levels and activity of DNase1, impairing NET degradation, and suggests DNase1 administration as a potential treatment.

In this study, proteolytic enzymes applied to mice skin caused severe degeneration in hair follicles, including detachment of stem cells from their niche, suggesting potential impairment of stem cell function.

This study purified a transglutaminase enzyme from human epidermis that requires calcium or strontium for activity and forms cross-linked polymers, but its detailed activation mechanism remains unclear.

This abstract provides a comprehensive overview of enzyme classification, function, and interaction with drugs, but does not present new research findings.

This study found that enzyme depilation of lambskins can cause damage due to the removal of collagen VI, suggesting the need for a protease that avoids this interaction for successful application.

The researchers reported that applying proteolytic enzymes to mice skin negatively affected hair follicles, leading to degeneration and potential impairment of stem cells from the bulge area.

This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.

This study reported that patterns of fibrosis identified through elastin staining may help distinguish specific forms of primary cicatricial alopecia in biopsy specimens, with certain patterns suggesting particular diagnoses.

PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.

This study isolated and characterized two distinct types of caspase-like proteases from human epidermis, suggesting their involvement in keratinocyte differentiation and apoptosis processes.

This study found that astrotactin-2 undergoes unique intramembrane proteolysis during maturation, revealing specific transmembrane topologies and substrate sequence requirements for cleavage.

This review discusses the role of matriptase and its inhibitor HAI-1 in epithelial homeostasis and cancer development, highlighting their imbalance's link to cancer progression without presenting new experimental results.

RNase L suppresses regeneration in mammals.

This study used in-silico analyses to investigate papain's potential as a fibrinolytic agent and found that certain fibrin peptides displayed strong interactions with papain, suggesting it may be beneficial for cardiovascular disease treatment.

This study found that Mf-rich-fiber in human hair underwent significantly greater degradation by proteases than Ma-rich-fiber, especially when treated with Proteinase K.

This study found that cytokine and EGF stimulation leads to increased MMP-9 production in hair follicles, a process involved in hair follicle involution associated with alopecia.

This review examines the clinicopathologic features of perifollicular elastolysis and indicates that, while its presentation is consistent, there is a lack of high-certainty evidence for effective treatments.

This study reported that methanolic extracts from marine sponges, particularly Petrosia sp. and Agelas nakamurai, showed significant enzyme inhibitory activities, with Petrosia sp. exhibiting notable 5?-reductase inhibition.

This report describes the successful resolution of an epidermoid cyst using a minimally invasive approach with intralesional injection of recombinant enzymes.

This study found that the type IV collagenases, MMP-2 and MMP-9, play significant roles in the hair cycle, potentially through their influence on VEGF, IGF-1, and TGF-β expression.

This review discusses the potential of fibrinolytic enzymes from various sources, especially fermented foods, for their therapeutic use in cardiovascular diseases and emphasizes the need for further research on those from non-Asian regions to optimize discovery and application.

This study found that proteolytic activities in murine skin vary with hair cycle stages, with significant collagenase activity during the early anagen phase.

This study found that the catalytically inactive serine protease CAP1/Prss8 can still induce skin disorders in mice and is subject to inhibition by nexin-1, independent of its catalytic activity.