10 citations
,
January 2014 in “Journal of Pediatric Endocrinology and Metabolism” This study identified three new mutations in the VDR ligand-binding domain that may cause dysfunction, and noted that oral calcium and calcidol treatment was effective, but only one patient experienced hair growth.
277 citations
,
July 2002 in “Molecular Endocrinology” In this study, homozygous VDR null mutant mice exhibited nonfunctional vitamin D receptors, leading to growth abnormalities and revealing the limited physiological importance of vitamin D pathways outside the classical receptor.
71 citations
,
October 2014 in “The Journal of Steroid Biochemistry and Molecular Biology” This study highlights the complex role of the vitamin D receptor in skin processes, where its disruption, along with calcium and co-regulator imbalances, could contribute to skin cancer development by altering skin differentiation and hair follicle cycling.
This study found significant variability in the production and use of platelet-rich plasma and related products in Brazil, highlighting the need for regulatory measures to ensure safety.
15 citations
,
May 1987 in “Fundamental and applied toxicology” This study found that SMR-2 and SMR-6, analogs of retinoic acid and retinol, were approximately 100 times more toxic than retinoic acid in mice, inducing hypervitaminosis A and affecting various organs and tissues.
21 citations
,
February 2023 in “Bioengineering” This review outlines current European legislation and manufacturing standards for platelet-rich plasma (PRP) products and provides guidance for clinicians implementing autologous PRP treatments, without reporting new clinical results.
68 citations
,
November 2012 in “Journal of Investigative Dermatology” This study found that PGD2 inhibits hair follicle regeneration in mice through the Gpr44 receptor, suggesting that blocking PGD2 or Gpr44 may enhance skin regeneration after wounds.
50 citations
,
September 2009 in “Molecular Genetics and Metabolism” This study identified a novel V26M mutation in the vitamin D receptor as the cause of hereditary vitamin D resistant rickets in a patient, characterized by severe rickets and an unusual pattern of alopecia.
This chapter reviews current and future strategies for identifying ligands and functions of orphan G protein-coupled receptors, but it reports no new experimental results.
May 2026 in “Pharmaceuticals” This study analyzed safety data for semaglutide, liraglutide, and tirzepatide from the EudraVigilance database, identifying potential safety signals not listed in current SmPCs, such as optic ischemic neuropathy and pancreatitis, underscoring the importance of ongoing pharmacovigilance.
2 citations
,
April 2019 in “Proceedings of Singapore Healthcare” This study found that a collaborative care model in rheumatoid arthritis clinics improved nb-DMARD dose optimization, adherence to monitoring guidelines, and detection of related adverse drug events compared to standard care.
2 citations
,
February 2024 in “Journal of the European Academy of Dermatology and Venereology” This study resulted in a draft version of the Patient‐Reported Impact of Dermatological Diseases measure, PRIDD, which includes 27 items refined from patient consensus and is now undergoing psychometric testing.
148 citations
,
May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mice lacking the vitamin D receptor (VDR) developed skin tumors more rapidly than those with normal VDR activity, regardless of 1,25-dihydroxyvitamin D(3) presence.
2 citations
,
March 2023 in “Experimental neurology” In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.
2 citations
,
January 2008 in “Cuadernos de Psiquiatría comunitaria” This review examines how vitamin D and its receptor regulate various skin functions, such as cell differentiation and immunity, and explores the mechanisms involved, without reporting new clinical results.
17 citations
,
October 2023 in “Molecules” In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.
2 citations
,
April 2018 in “Current Pharmaceutical Analysis” This study developed a new, simple, and economical RP-TLC method with densitometry that is suitable for routine analysis of finasteride in tablet dosage form, meeting analytical validation criteria.
1 citations
,
November 2025 in “Clinical Chemistry and Laboratory Medicine (CCLM)” This study developed a new measurement procedure using isotope dilution-liquid chromatography-tandem mass spectrometry for accurate quantification of DHEAS in human serum or plasma, demonstrating high selectivity, sensitivity, and low measurement uncertainty, making it suitable for routine standardization and clinical evaluation.
18 citations
,
September 2016 in “International Journal of Molecular Sciences” This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.
98 citations
,
February 2010 in “Dermatology Online Journal” This article outlines the potential for upregulating the vitamin D receptor in treating hair disorders, emphasizing the need for further studies to evaluate vitamin D's role in the hair cycle.
9 citations
,
January 2018 in “Plastic and Reconstructive Surgery – Global Open” Using PDRN injections and RF treatments improved revision nose surgery results without major side effects.
13 citations
,
April 2021 in “Value in Health” This review categorizes 59 modifications of the Dermatology Life Quality Index across multiple studies, highlighting the need for further validation of these customized health-related quality of life tools in dermatology.
June 2026 in “Journal of Cosmetic Dermatology” PDRN may help with female hair loss, but more research is needed.
60 citations
,
December 1988 in “Journal of Biochemical Toxicology” In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.
44 citations
,
October 2016 in “Epilepsia” This study demonstrated that the glycolytic inhibitor 2-deoxy-D-glucose enhances antiseizure effects by potentiating extrasynaptic tonic GABAergic inhibition through neurosteroidogenesis in hippocampal slices.
2 citations
,
August 2025 in “Pharmaceutics” This review compares DNA-derived biopolymers, PN and PDRN, in dermatology, emphasizing their distinct molecular characteristics and roles, and reports no new clinical results.
12 citations
,
November 2022 in “Toxics” This review describes how liver and kidney diseases and diabetes may affect ethyl glucuronide levels in hair, impacting forensic and clinical interpretations, but reports no new experimental results.
42 citations
,
August 1999 in “The American journal of pathology” This study found that basal cell carcinomas show strong expression of vitamin D receptors at both mRNA and protein levels, suggesting a potential role in tumor growth regulation.
34 citations
,
July 2011 in “International journal of pharmaceutics” This study found that ion-paired solutions significantly improved the skin penetration of risedronate in hairless mice compared to risedronate alone.
May 2015 in “Primary Dental Journal” The conclusion is that improved training and oversight for cosmetic procedures are recommended to better protect patients.