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This article reviews the definitions, opportunities, advantages, and limitations of dental pulp stem cells and stem cells from human exfoliated deciduous teeth in tissue engineering and regenerative medicine, reporting no new clinical results.

This study found that overexpressing the gene Thymosin β4 (Tβ4) can promote the growth and development of secondary hair follicle dermal papilla cells in cashmere goats, suggesting its potential as a target for increasing cashmere production.

This study found that circAGK was highly expressed in AGA patients and promoted dermal papilla cell apoptosis, suggesting it as a potential target for treating androgen alopecia.

ATP-sensitive potassium channels are important for hair growth.

This study found that co-culturing dermal papilla cells in a 3D structure with adipose-derived stem cells may enhance the expression of hair inductivity markers compared to 2D cultures.

This study found that non-balding dermal papilla cells emphasized extracellular matrix organization and reduced inflammation when cultured in 3D or with adipose-derived stem cells, unlike balding cells which maintained inflammatory pathways.

This review discusses how dental pulp stem cells and their derivatives may accelerate skin wound healing by modulating inflammation, promoting angiogenesis, optimizing extracellular matrix structure, and enhancing tissue formation, with implications for translating these findings into therapies for skin and mucosal repair.

This study found that conditioned medium from human dental pulp stem cells (particularly under hypoxic conditions) improved keratinocyte survival and hair regrowth in a chemotherapy-induced alopecia mouse model and did not promote tumor growth, suggesting potential for safe therapeutic use.

This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.

In this study, androgen did not affect keratinocyte growth in coculture with androgenetic alopecia-derived dermal papilla cells, but did significantly suppress keratinocyte growth when androgen receptor was overexpressed in the papilla cells.

This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.

This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.

This study found that EGCG from green tea may stimulate human hair growth by promoting the proliferation and anti-apoptotic activity in dermal papilla cells.

This study found that poly(ethylene-co-vinyl alcohol) membranes support the self-assembly of dermal papilla cells into compact spheroidal microtissues capable of inducing new hair follicles, suggesting potential for large-scale production for hair follicle regeneration.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.

This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.

This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.

The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.

In this study using a mouse model, the researchers found that platelet-rich plasma significantly increased the number of newly formed hair follicles and decreased the time for hair formation compared to no treatment.

This study observes the expression of mRNA for androgen receptor, 5α‐reductase, and 17β‐hydroxysteroid dehydrogenase in human dermal papilla cells.

This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.

This study observed that androgen treatment increased ROS production and TGF-β1 secretion in rat hair follicle dermal papilla cells, suggesting that the androgen-induced TGF-β1 is mediated by ROS.

This study found that dermal papilla cells from beard and axillary hair follicles can produce androgen-dependent factors that stimulate proliferation in adjacent follicular epithelial cells under testosterone influence.

In this study, decreased expression of BMP2 and ephrin A3 and increased NT-4 gene expression were observed in dermal papilla cells from androgenic alopecia-affected skin, suggesting potential roles in hair growth regulation.

This study found that insulin-like growth factor-I and hepatocyte growth factor increased the chemotactic migration of human hair outer root sheath cells, suggesting these factors have both growth stimulatory and chemotactic effects.

This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.

This study identified several DPC-specific proteins, including ITGB1, IGFBP3, and THBS1, as potential biomarkers for hair growth modulation through proteomic and network analysis.

This study indicates that Fructus panax ginseng extract may promote hair growth by increasing proliferation in human hair dermal papilla cells and lengthening the anagen phase in mice.

This study found that combining herbal extracts with PRP increased human dermal papilla cell proliferation via ERK and Akt protein regulation, suggesting its potential for developing hair growth therapies.