Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study used molecular docking to analyze nine compounds from the Siddha herbal formulation Kushtakudori ennai, finding that they may effectively interact with androgen receptors to hinder hair follicle shrinkage and potentially reduce hair loss, showing potential as anti-alopecia treatments.

In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.

This in-silico study identified several compounds as potential Vitamin D Receptor agonists, with Dolichosterone showing the strongest binding energy.

This study found that finasteride's solubility and bioavailability were improved when using a dimethyl-β-cyclodextrin inclusion complex compared to the drug alone.

This study suggests that polygonum multiflorum may treat androgenic alopecia by mediating the PI3K/Akt pathway to regulate apoptosis, inhibit inflammation and oxidative stress, and induce melanin production.

This study suggests that BRAF inhibitors, particularly Encorafenib and Dabrafenib, may have potential applications in wound healing by targeting specific proteins involved in the healing process in murine models.

This molecular docking study reported that danoprevir, remdesivir, and saridegib exhibit stronger binding affinities to the main protease of SARS-CoV-2 than the control, suggesting their potential as inhibitors of the virus's replication process.

This study reported that among 10 tested 2-(4-chlorophenyl)-5-aryl-1,3,4-oxadiazole compounds, compound 4c showed the highest activity against cancer cell lines, with a 95.37% average growth rate.

This study found that MEGA PROTAC improved the prediction of ternary structures with higher maximum DockQ scores compared to the BOTCP method in 16 out of 22 test cases.

This study found that a synthetic avicequinone C analogue, 5e, was significantly more potent in inhibiting steroid 5α-reductase type 1 activity in human keratinocytes compared to the original isolated compound.

This study found that undiluted mint leaf extract effectively inhibited multidrug-resistant Staphylococcus aureus and killed Culex pipiens larvae, suggesting its potential as a biocontrol strategy around hospitals.

In this study, different drying methods for Hedychium spicatum rhizomes significantly affected the essential oil yield, antioxidant potential, and compound composition, with the HSOV30 method yielding the highest oil content, antioxidant activity, and specific compound levels such as 1,8-cineole and elemol.

This study suggests that Gujian oral liquid may reduce osteoarthritis symptoms by regulating inflammation and catabolism through the TNF-α/NF-kappa B signaling pathway, as confirmed by both in vivo and in vitro experiments.

In this study, researchers using network pharmacology and molecular docking methods found that compounds from Avicennia Marina could inhibit hepatitis C virus infection by targeting key proteins such as AKT1 and TNF-α, showing potential for anti-HCV treatments.

This study investigated the effects of Taohong Siwu Decoction on deep vein thrombosis, identifying 56 potential targets and highlighting beta-sitosterol, quercetin, and kaempferol as key active components that may regulate inflammation through the PI3K/Akt pathway, potentially slowing disease progression.

This study predicted that key components of Platycladi Cacumen, such as quercetin and apigenin, may have stable binding interactions with targets involved in androgenetic alopecia.

This study investigated the mechanisms of Platycladi Cacumen in treating androgenetic alopecia, identifying potential key components and targets but found no specific targets or regulatory mechanisms.

In this study, researchers used a network pharmacology approach to highlight significant interactions between compounds in rosemary (Salvia rosmarinus) and genes related to functional dyspepsia, suggesting potential pathways for developing treatments against gastrointestinal diseases.

This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.

In this study, researchers found that Compound Baqian Danshen Liniment may improve vitiligo in mice by promoting melanocyte activity and reducing inflammation and oxidative stress.

This study found that supplemented Erzhi Wan enhanced hair regrowth in a mouse model of androgenetic alopecia and identified potential mechanisms through oxidative stress and signaling pathways.

This study found that compounds extracted from Cucurbita maxima seeds at 50 °C for 2 hours demonstrated significant binding affinities against breast cancer-related proteins, suggesting potential anticancer activity needing further in vitro and in vivo evaluation.

This study used machine learning to identify FDA-approved drugs afatinib, neratinib, and zanubrutinib as potential KRASG12C inhibitors for resistant non-small-cell lung cancer, highlighting the potential of AI in drug repurposing.

This study found that extracts from Hom Thong banana peels, rich in phenolic compounds, may inhibit melanin production in human and mouse melanoma cells, showing potential as anti-melanogenic agents comparable to standard treatments like arbutin and kojic acid.

Andrographolide from Andrographis paniculata promotes hair growth and could be a natural treatment for hair loss.

This study found that the extracts of Serenoa repens, when evaluated through chemical, biological, and in silico methods, demonstrated anti-inflammatory, pro-apoptotic, and anti-androgenic activities against prostate cancer cell lines, suggesting potential therapeutic benefits and directing future pharmaceutical development.

This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.

This study found that Dock5 plays a crucial role in keratinocyte function and wound healing, with its expression reduced in diabetic models but improving healing when restored.