Mechanistic Insights on Dyspepsia Modulation by Salvia Rosmarinus Through Network Pharmacology, Molecular Docking, and Molecular Dynamics
August 2025
in “
Processes
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Studysummary In this study, researchers used a network pharmacology approach to highlight significant interactions between compounds in rosemary (Salvia rosmarinus) and genes related to functional dyspepsia, suggesting potential pathways for developing treatments against gastrointestinal diseases.
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The study explores the potential of Salvia rosmarinus (rosemary) in treating dyspepsia through network pharmacology, molecular docking, and molecular dynamics. It identifies significant interactions between rosemary compounds and dyspepsia-related genes, with luteolin showing strong binding affinity and stability, surpassing conventional treatments like omeprazole and lansoprazole. The research highlights the role of protein-protein interactions and pathway enrichment, particularly involving the proto-oncogene c-Kit, suggesting that rosemary's bioactive compounds could serve as a basis for developing pharmaceuticals targeting gastrointestinal diseases like dyspepsia. The findings indicate that luteolin, with its favorable bioavailability and reduced side effects, could be a promising natural therapeutic agent for functional dyspepsia.
