5 citations
,
June 2021 in “Pharmacological Reports” This study suggests that vitamin D treatment may be less effective in reducing thyroid autoimmunity for euthyroid men with early-onset androgenic alopecia compared to other men with autoimmune thyroiditis.
3 citations
,
September 2019 in “PLOS ONE” In this study, the authors identified the DHRS9 SNP rs72623193 as most significantly associated with response to dutasteride in treating male pattern hair loss, with additional variants potentially contributing.
November 2025 in “Discover Pharmaceutical Sciences” In this study, a nanoemulsion containing lavender, peppermint, and rosemary essential oils was developed and shown to promote hair growth in mice at a rate comparable to 2% topical minoxidil, suggesting a promising natural alternative due to its antioxidant and anti-inflammatory effects.
87 citations
,
December 2015 in “Cochrane library” This review observed limited evidence of clinically significant benefits from treatments for acute central serous chorioretinopathy, which often resolves spontaneously, but identified PDT and micropulse laser as the most promising for further trials.
June 2020 in “AACE clinical case reports” This case report illustrates that Leydig cell tumors, despite causing significantly elevated androgen levels, can be difficult to localize due to their small size, as demonstrated in a 42-year-old woman whose tumor was only identified after oophorectomy.
May 2026 in “Revista Iluminart” In this study, researchers found that adding coffee grounds to neutral shampoo, a popular DIY trend, resulted in peak caffeine extraction after seven days, with concentrations surpassing those in commercial products, suggesting educational potential for chemistry classes.
1 citations
,
April 2021 in “Clinical and Experimental Dermatology” The COVID-19 pandemic has caused a 57% increase in interest in facial cosmetic procedures, leading to calls for better industry regulation and professional standards.
2 citations
,
April 2007 in “Journal of Labelled Compounds and Radiopharmaceuticals” This article discusses the preparation of tritium-labeled testosterone metabolites and reports no new experimental findings.
February 2016 in “PubMed” This review discusses testosterone replacement therapy, highlighting that most studies report no increased myocardial infarction risk when the therapy is properly administered with controlled hormone levels; it calls for careful consideration despite insurance coverage challenges.
3 citations
,
January 2018 in “Frontiers in bioscience” This retrospective analysis reported significant increases in testosterone levels in men with testosterone deficiency using the Daily Subcutaneous Testosterone method combined with hCG and anastrozole, indicating its potential as a treatment option.
February 2023 in “IntechOpen eBooks” This article discusses the various administration methods and considerations for testosterone replacement therapy, highlighting the importance of individualized therapeutic monitoring and potential adverse effects, but reports no new clinical results.
41 citations
,
November 2024 in “Molecular Biomedicine” This review discusses the mechanisms and engineering techniques for enhancing the targeted delivery of extracellular vesicles in therapies but reports no new clinical findings; the authors encourage further exploration to advance clinical applications.
25 citations
,
March 2000 in “Journal of Endocrinological Investigation” Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.
1 citations
,
January 2021 4 citations
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September 1993 in “Steroids” This paper details a method for measuring testosterone metabolism into seven androgens using digital autoradiography, which offers high sensitivity and reduces the need for radioactive materials.
January 2005 in “Journal of Investigative Medicine” This study found that testosterone therapy improved physical performance, strength, lean body mass, and serum cholesterol in older men with low testosterone levels, with or without the addition of finasteride.
162 citations
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April 2016 in “The Lancet Diabetes & Endocrinology” This review discusses the effects of testosterone therapy for transgender men, noting desired outcomes and potential risks, but reports no new research findings; the authors highlight a lack of high-quality data due to various study limitations.
7 citations
,
January 2021 in “The Journal of Sexual Medicine” This study demonstrated that testosterone treatment increases muscle strength and alters body composition in transmen, and the addition of dutasteride does not impair these anabolic effects.
6 citations
,
April 2019 in “Endocrinology and Metabolism Clinics of North America” This study observed that testosterone therapy in transgender men enhances both physical and mental health, is safe in the short and middle term with proper follow-up, and highlights the need for endocrinologists to provide gender-affirming care despite its limited presence in medical education.
122 citations
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November 2014 in “BMC Medicine” This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.
December 2016 in “The Journal of Sexual Medicine” This study reviewed the preferences and reasons for testosterone injection therapy among 53 Canadian men with hypogonadism, finding that most opted for injections due to efficacy, ease, and cost considerations.
53 citations
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July 2014 in “American Journal of Physiology-Endocrinology and Metabolism” This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.
2 citations
,
March 2012 in “Nature Reviews Endocrinology” The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.
110 citations
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April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.
1 citations
,
January 2010 in “Endocrine abstracts”
5 citations
,
January 2017 in “Endocrinology” This chapter reviews the biosynthesis, mechanism of action, and therapeutic effects of testosterone and related androgens, but reports no new research findings.
This study reports that testosterone requires conversion to DHT and estradiol for its various actions on external genitalia and bone, influencing lean mass, muscle size, strength, and body fat in hypogonadal males.
105 citations
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June 2010 in “The journal of sexual medicine” In this study, female-to-male transsexuals treated with long-acting testosterone undecanoate experienced an increase in lean mass but no change in fat mass or bone mineral density over 24 months.
May 2023 in “IntechOpen eBooks” This review outlines the role of testosterone in male sexual development and its therapeutic use for male hypogonadism, covering its biosynthesis, secretion, metabolism, and various biological actions, but does not report specific study results.
72 citations
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October 1998 in “Baillière's clinical endocrinology and metabolism” This article discusses the potential effects of exogenous testosterone, highlighting that its impact on prostate cancer progression, cardiovascular health, and behavior remains uncertain and needs further investigation.