Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that the unique functions of keratin 16 are likely determined by its tail domain, challenging the previous hypothesis about the role of the helix 1B subdomain.

This study found that polyamines enhance genome integrity by facilitating homologous recombination-mediated DNA repair, suggesting a novel role for polyamines beyond promoting cell growth and proliferation.

This study found that the cocrystal of mycophenolic acid with isonicotinamide significantly improved solubility and dissolution rate, while two other cocrystals showed decreased performance in these areas.

This study demonstrated that urea significantly accelerates the diffusion of poly(ethylene imine) into bleached human hair by increasing the diffusion coefficient twofold.

This source highlights the utility of cationic polymers in haircare products for protecting against hair damage from chemical treatments and grooming, and describes how microfluorometry can measure polymer deposition and penetration on hair fibers.

This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.

Keratin structure changes during keratinization, but the exact model remains uncertain.

This review summarizes recent advances in understanding intermediate filament structure and their implications for pathological mutations and human diseases, but it reports no new experimental results.

This study found that skin exposure to toluene diisocyanate in mice creates immune-recognition reservoirs in the skin's stratum corneum and hair follicles, potentially leading to sensitization and allergic reactions.

This study found that using poly(ethylene imine) as a counterion reagent improved the colorability and shampoo fastness of bleached human hair when dyed with an acid dye.

This study found that DGAT1 exhibits additional acyltransferase activities in vitro, including MGAT, wax synthase, and ARAT activities, suggesting these could be relevant to its in vivo functions.

This study found that the protein Formin 2 helps regulate cell-to-cell transport in thale cress by stabilizing actin filaments at plasmodesmata, with its absence leading to increased permeability and vulnerability to viral infections.

This study observed that insulin-dependent diabetes induces specific molecular changes in the keratin structure of hair, potentially offering a new way to study diabetic complications through easily accessible tissues.

This structural study reports on the crystal properties of a compound used for treating alopecia, revealing different conformations and nitrogen hybridization in its piperidine rings.

This study developed a model showing that keratin elasticity in skin may be influenced by electrostatic and bridging interactions between keratin filaments, contingent on the balance of charges in the surrounding medium.

This study found that Par3 plays a crucial role in maintaining epidermal homeostasis by regulating Rho/actomyosin contractility and ensuring mitotic accuracy, with potential implications for other self-renewing epithelia.

This study explored the solubility and crystal structure of GI197111X, a 5-alpha reductase inhibitor for androgenetic alopecia, finding its solubility in Capmul MCM suitable for a soft gel dosage form.

This study observed that DMAP scaffolds in a full-thickness wound model promote dermal appendage regeneration by activating humoral immunity, specifically through B cell activation and antibody production, even when adaptive immune cells' infiltration is restricted.

This study found that dihydromyricetin may reduce fibrosis features in hypertrophic scars by affecting PI3K/AKT/mTOR signaling, but further research is needed to confirm causality.

This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.

This study conducted molecular docking and ADME property analysis on 144 newly designed isatin analogs, suggesting they exhibit lead-like properties for targeting EGFR enzymes.

This study found that dimethylarsinic acid significantly accelerates skin tumor development in hair follicle-targeted K6/ODC transgenic mice.

This study investigated improving Finasteride's water solubility using trimethyl-β-cyclodextrin (TM-β-CD) and β-cyclodextrin (β-CD) as carriers, finding that β-CD improved Fin's cumulative release, while TM-β-CD enhanced its solubility, with computational data supporting these outcomes.

In this study, Rahim et al. found that keratinocyte differentiation requires changes in polyamine ratios mediated by AMD1, suggesting that targeting polyamine availability could be useful for treating hyperproliferative skin disorders.

This study found that the desolvation of finasteride hydrate solvates is highly dependent on the physical environment, complicating investigations but providing insight through complementary analysis techniques.

This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.

This study found that while Eda and Edar proteins interact in vitro, their roles in dental development differ, with downless mutant mice showing distinct tooth defects compared to tabby mutants.

In this study, the authors developed a novel PROTAC named dAR-6–1, which demonstrated superior hair regeneration in an AGA mouse model compared to minoxidil, highlighting its promise as a therapy due to potent AR degradation and excellent skin permeability.