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    Glossary Diane

    medication combining cyproterone acetate and ethinylestradiol for acne and hirsutism

    Diane, also known as Diane-35, is a medication that combines cyproterone acetate and ethinylestradiol. It is primarily used to treat severe acne and hirsutism (excessive hair growth) in women, and it also functions as a contraceptive. The cyproterone acetate component acts as an anti-androgen, reducing the effects of male hormones that can cause acne and hair growth, while ethinylestradiol is a synthetic estrogen that helps regulate the menstrual cycle.

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    1. Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study Clinical Endocrinology · 2012 · 150 citations
    2. Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism Fertility and Sterility · 2001 · 63 citations
    3. Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism Fertility and Sterility · 2000 · 50 citations
    4. The Development and Evaluation of An Ovulation Inhibitor (Diane®) Containing An Antiandrogen Acta obstetricia et gynecologica Scandinavica · 1979 · 33 citations
    5. A comparative study of Aldactone® and Diane® in the treatment of hirsutism 1987 · 20 citations
    6. [Assessment of efficacy of Diane-35 in androgenetic feminine alopecia]. PubMed · 2003 · 12 citations
    7. Thrombotic risk minimization for Diane‐35 and generics Pharmacoepidemiology and Drug Safety · 2017 · 7 citations
    8. A Comparative Study of Diane‐35 plus Spironolactone and Diane ‐35 Plus Finasteride in Cases of Hirsutism and Acne International Journal of Endocrinology and Metabolism · 2009 · 4 citations
    9. A case of severe hyperandrogenism, acanthosis nigricans and overt diabetes: the use of non-invasive methods for diagnosis, pathogenesis and management Gynecological endocrinology · 1996 · 1 citations
    10. [Treatment of moderately severe virilism of women with Diane and Androcur 10]. PubMed · 1983
    11. Pharmacokinetic and Therapeutic Dose Comparison of Diane-35 and IVF-C Inj 5000 IU in Common Quail International Journal of Pharmacology · 2025
    12. The Effect of Hysteroscopy Combined with Diane-35 on Endometrial Polyps and Its Impact on the Recurrence Rate Advances in obstetrics and gynecology research · 2024
    13. [Experience in treating androgen-dependent diseases (androgenetic alopecia, acne agminata, hirsutism) with the preparation Diane]. PubMed · 1986
    14. Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression Human Reproduction Update · 2018 · 189 citations
    15. Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes Diabetes · 2011 · 53 citations
    16. Association of Androgenetic Alopecia With Mortality From Diabetes Mellitus and Heart Disease JAMA Dermatology · 2013 · 49 citations
    17. Hair corticosterone measurement in mouse models of type 1 and type 2 diabetes mellitus Physiology & Behavior · 2017 · 32 citations
    18. The skin landscape in diabetes mellitus. Focus on dermocosmetic management Clinical Cosmetic and Investigational Dermatology · 2013 · 31 citations
    19. Effect of composite biodegradable biomaterials on wound healing in diabetes Frontiers in Bioengineering and Biotechnology · 2022 · 25 citations
    20. Diabetes and Skin — A Review Scottish medical journal · 1974 · 24 citations
    21. Hyperprogesteronismus infolge bilateraler Nebennierenrindenkarzinome bei einer Katze mit Diabetes mellitus Schweizer Archiv für Tierheilkunde · 2009 · 16 citations
    22. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis Hormone Molecular Biology and Clinical Investigation · 2014 · 15 citations
    23. Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus BMB Reports · 2022 · 13 citations
    24. Hair follicle characteristics as early marker of Type 2 Diabetes Medical Hypotheses · 2016 · 13 citations
    25. Diabetes mellitus: interdisciplinary medical, surgical and psychological therapeutic approach Journal of Mind and Medical Sciences · 2023 · 12 citations
    26. Skin, a mirror reflecting diabetes mellitus: A longitudinal study in a tertiary care hospital in Gujarat Indian Journal of Endocrinology and Metabolism · 2013 · 11 citations
    27. Effect of Type 2 Diabetes Mellitus on the Pharmacokinetics of Metformin in Obese Pregnant Women Clinical Pharmacokinectics · 2012 · 10 citations
    28. Method for chronological recording of antigen appearance in human head-hair shafts and its use for monitoring glycation products in diabetes Journal of immunological methods · 2006 · 7 citations
    29. Incipient Diabetes Mellitus and Nascent Thyroid Disease Presenting as Beard Alopecia Areata: Case Report and Treatment Review of Alopecia Areata of the Beard Curēus · 2020 · 5 citations
    30. Non-invasive evaluation of advanced glycation end products in hair as early markers of diabetes and aging Scientific Reports · 2025 · 4 citations