Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review examines the pharmacological properties and potential clinical benefits of 5α‐reductase inhibition in prostate cancer but reports no new research findings.

This study found that low doses of bisphenol A may increase proliferation of the ventral prostate in adult rats by altering the estrogen to androgen ratio and gene expression.

Male hormones control a specific gene in hamster skin, with different hormones having varying effects.

This review evaluates the use of 5α-reductase inhibitors in feminising hormone therapy, finding their additive feminising benefits unclear due to their specific action on testosterone conversion, with concerns highlighted regarding limited supporting evidence and safety signals, particularly for psychiatric and sexual effects.

This study concluded that among men with normal testosterone levels, a small increase in serum dihydrotestosterone may reduce symptoms of hypogonadism, suggesting its potential diagnostic use after ruling out hypogonadism.

In this study, PFOS exposure altered steroid hormone levels and enzyme activities related to steroidogenesis in juvenile Silurana tropicalis, with effects differing between male and female frogs.

This article describes the growth and characteristics of saw palmetto and its fruit but reports no new research results.

This study found that high prepubertal and pubertal androgen levels, originating from both adrenal and gonadal secretion, were negatively associated with adult height outcomes in males with Silver-Russell syndrome.

This investigation found that certain supplements, particularly whey protein isolate, growth hormones, and anabolic steroids, can negatively impact hair loss by affecting biochemical pathways.

In this study, lower dihydrotestosterone and higher testosterone levels were linked to increased brain activation during response inhibition, although no behavioral changes were detected.

This study found that chronic administration of dutasteride in rats did not affect spermatogenesis or oxidative stress in the testes, although it altered hormone levels.

This study found that administering dutasteride did not change spermatogenesis or oxidative stress levels in rat testes, though further research is needed to confirm these findings.

In this study, testosterone was found to increase the risk of arrhythmias in a rat heart model, while finasteride reduced this arrhythmogenic effect.

This review concluded that 5α-reductase inhibitors like finasteride and dutasteride offer limited additional feminising effects in hormone therapy for transfeminine individuals, with the clearest use being androgenetic alopecia treatment; more research is needed for other potential benefits.

This study observed that "physiological" hyperandrogenism due to elevated total testosterone was associated with a 23.5% incidence of arterial hypertension, unlike hyperandrogenism due to elevated DHT levels.

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.

Mutations in the androgen receptor gene cause androgen insensitivity, leading to female traits in genetically male individuals.

This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.

This study indicates that insulin changes sex hormone levels in insulin-resistant women with polycystic ovary syndrome without affecting gonadotropin release, challenging the idea that hyperinsulinemia directly causes hyperandrogenism in PCO.

This study found significant species differences in the enzyme activity and inhibitor affinities of prostatic 5α-reductases from rats, dogs, and humans, with variable potencies for different 3-oxo-4-azasteroid inhibitors across species.

This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.

This abstract reviews the role of finasteride and potential dual 5alpha-reductase inhibitors in treating benign prostatic hyperplasia, suggesting that dual inhibitors may offer greater DHT suppression and therapeutic advantages, while emphasizing the need for clinical evaluation.

Male and female mice have different skin thickness, and hormones affect their skin and hair growth differently.

This review outlines the complexities of understanding DHT biosynthesis and metabolism in the human prostate and reports no new findings, emphasizing the need for further research into the pathways involved.

This article reviews potential prevention and intervention strategies for prostate cancer, including 5alpha-reductase inhibition, but reports no new clinical findings.

This study found that finasteride significantly suppresses serum dihydrotestosterone levels at all tested doses in normal male volunteers without significant adverse effects.

This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

This article reviews how different 5alpha-reductase and 3alpha-HSD enzymes impact androgen levels and highlights their potential as drug targets for androgen-related diseases, but provides no new experimental findings.