Pharmacologically Altered Androgens, Brain Activation, and Response Inhibition in a Stop-Signal Task in Male Heavy Drinkers

    January 2026
    Sarah Gerhardt, Rafat Boroumand-Jazi, Sabine Hoffmann … Marlene Kundlacz
    Studysummary In this study, lower dihydrotestosterone and higher testosterone levels were linked to increased brain activation during response inhibition, although no behavioral changes were detected.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on researchsquare.com →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men Journal of Clinical Psychopharmacology · 2024
    2. The Connection of 5-Alpha Reductase Inhibitors to the Development of Depression Biomedicine & Pharmacotherapy · 2021
    3. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    4. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    5. Prenatal and Adult Androgen Activities in Alcohol Dependence Acta psychiatrica Scandinavica · 2017
    6. Exploring the Neural Mechanisms of Finasteride: A Proteomic Analysis in the Nucleus Accumbens Psychoneuroendocrinology · 2016
    7. On the Effects of Testosterone on Brain Behavioral Functions Frontiers in Neuroscience · 2015
    8. A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride Clinical Pharmacology & Therapeutics · 1998