1 citations
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May 2025 in “Scientific Reports” In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.
In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.
June 2021 in “Archives of Advances in Biosciences” This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.
195 citations
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February 2007 in “The Journal of Clinical Endocrinology and Metabolism” In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.
18 citations
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May 1992 in “American Journal of Biological Anthropology” This study found no general elevation in androgen levels among men predisposed to balding, despite a correlation with the free-to-total testosterone ratio; no link was observed with acne.
4 citations
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June 2017 in “Endocrine Reviews” Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.
March 2025 in “Journal of Endocrinology and Metabolism” This study found that while rat models treated with letrozole and dihydrotestosterone exhibit altered sterol, leukotriene, and steroid hormone profiles similar to human PCOS, significant differences remain.
305 citations
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February 2007 in “Hormone and metabolic research” This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.
146 citations
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January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
76 citations
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October 2016 in “Clinics in dermatology” This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.
56 citations
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April 1998 in “Steroids” Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.
43 citations
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January 2006 in “PubMed” This article summarizes findings on the role of androgens and estrogens in male reproductive tissues across species, highlighting the roles of hormone metabolism, receptor distribution, and stress-induced changes.
35 citations
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December 2009 in “Human reproduction” This study found that metformin treatment during pregnancy in women with PCOS was associated with higher SHBG levels in newborns, but did not affect androgen or estrogen levels at birth.
35 citations
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September 1972 in “Journal of Biological Chemistry” This study observed that the binding of certain hormones in rat skin varies cyclically with the hair cycle phases, with testosterone showing maximum binding in the catagen phase.
33 citations
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January 2013 in “Dermatology” This study found that among women above 15 years with acne, 54.56% exhibited hyperandrogenism, with dehydroepiandrosterone sulfate levels most frequently elevated.
29 citations
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February 2004 in “Experimental and Clinical Endocrinology & Diabetes” This study suggests that many men with premature balding exhibit a hormonal pattern similar to some aspects of polycystic ovary syndrome in women.
28 citations
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November 2017 in “Molecular and cellular endocrinology” This review examines the roles of testosterone, dihydrotestosterone, and estradiol in activating male sexual behavior in laboratory animals and humans, reporting no new clinical results.
25 citations
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October 1993 in “American Journal of Physical Anthropology” This study observed that in Namibian/Southern African men, hormone levels, particularly estradiol, influence the growth of body hair, with different effects noted in various ethnic groups.
20 citations
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June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.
13 citations
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July 2018 in “General and comparative endocrinology” This study observed that direct exposure to androgens in Western clawed frogs differentially affects thyroid receptor and deiodinase gene expression in male and female tissues, offering insight into sex-specific metabolic pathway activation.
12 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.
9 citations
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October 2018 in “Medical Science Monitor” In this study, oral finasteride therapy was associated with decreased DHT levels and improved hair loss severity in young male AGA patients, while hormonal changes influenced the curative effect.
9 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the in vitro growth of hair follicle cells, particularly papilla cells and outer root sheath keratinocytes, is influenced by different concentrations of androgens and antiandrogens.
7 citations
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October 2017 in “The Prostate” This study found that male pattern baldness may serve as a clinical marker for circulating sex hormone levels in men with localized prostate cancer, while chest hair density showed no significant hormone association.
4 citations
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March 2019 in “JAT. Journal of applied toxicology/Journal of applied toxicology” In this study, PFOS exposure altered steroid hormone levels and enzyme activities related to steroidogenesis in juvenile Silurana tropicalis, with effects differing between male and female frogs.
4 citations
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January 1994 in “Journal of hepatology” This study observed that cyclosporine A significantly alters sex hormone levels in both pre- and post-menopausal women with primary biliary cirrhosis.
3 citations
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May 2024 in “Frontiers in Physiology” In this study, male rats with spinal cord injury that received either E2 or DHT supplementation both showed restored expression of respiratory neuroplasticity following acute intermittent hypoxia, with E2 also enhancing overall breathing recovery.
2 citations
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March 2020 in “Baghdad Science Journal” This study found that among men with Benign Prostatic Hyperplasia, treatment with the 5α-reductase inhibitor finasteride for three months significantly reduced levels of dihydrotestosterone and estradiol, hormones involved in prostate enlargement, without altering follicle-stimulating hormone or luteinizing hormone levels.
2 citations
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October 2021 in “Exploration of targeted anti-tumor therapy” This review describes oncotherapy-induced alopecia in patients receiving hormone therapy for hormone-receptor-positive breast cancer and concludes that topical hormones should not be used due to oncogenic potential.
2 citations
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January 2019 Hormonal contraceptives and therapies regulate organ functions and treat various conditions.